Pestana Organ Transplantation

Question 1

absolute contraindication to organ donation

Answer 1

HIV+ status

Question 2

3 ways transplant rejection can happen

Answer 2

hyperacute
acute
chronic

Question 3

When does hyperacute rejection occur?

Answer 3

within MINUTES of reestablishing blood supply to the transplanted organ - caused by preformed antibodies

Question 4

How do you prevent hyperacute rejection?

Answer 4

ABO matching and lymphocytotoxic cross-matching

Question 5

When does acute rejection occur?

Answer 5

> 5 DAYS but within the first 3 MONTHS

Question 6

What should you do if LFTs begin to rise in a patient with transplanted liver?

Answer 6

R/O biliary obstruction by US and vascular thrombosis with Doppler

Question 7

Management of a patient with transplanted heart?

Answer 7

routine ventricular biopsies since signs of functional deterioration usually occur too late to allow effective therapy

Question 8

Treatment of acute rejection?

Answer 8

Steroid boluses (1st line)
Lympocyte agents (OKT3)
Antithymocyte serum

Question 9

When does chronic rejection occur?

Answer 9

YEARS, with insidious loss of organ function

Question 10

Treatment of chronic rejection?

Answer 10

no treatment