Personalized Medicine (Darbro)

Question 1

Which of the following is NOT a component of personalized medicine?

A. the tailoring of medical treatment to the individual characteristics of each patient
B. the classification of individuals into subpopulations that differ in their susceptibility to a particular disease
C. the classification of individuals into subpopulations that differ in their response to a specific treatment
D. concentration of preventative or therapeutic interventions on those who will benefit
E. the creation of drugs or medical devices that are unique to a patient

Answer 1

E

Question 2

What decade is credited with the beginning of the “genomic era”?

Answer 2

1950s

Question 3

What was the first drug that became FDA-approved to treat conditions that were discovered from chromosome analysis?

Answer 3

Imatinib, aka Gleevac (2001)

Question 4

Which of the following drugs is incorrectly matched to the disease it treats?

A. Crizotinib: NSCLC (ALK mutation)
B. Imatinib: CML
C. Vemurafenib: colon cancer (KRAS mutation)
D. Gefitinib: EGFR mutation
E. Trastuzumab: HER2+ breast cancer

Answer 4

C. Vemurafenib is used to treat melanoma (BRAF mutation)

Question 5

test used for monitoring of cardiac transplant rejection

Answer 5

AlloMap