Peripheral Venous & Lymphatic Vessel Disease Flashcards

1
Q

What causes varicose veins

A

high venous pressure

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2
Q

Classic patient of varicose veins

A

Postpartum women (highest incidence)
Prolonged standing
Heavy lifting
Varicosities develop in over 20% of all adults

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3
Q

how does blood pool up?

A

Combination of progressive venous reflux and venous hypertension is the hallmark of chronic venous disease
Venous reflux - venous valve does not close appropriately leading to backward blood flow into lower extremities
Venous hypertension - increased venous pressure as a result of reflux

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4
Q

MC vein associated with varicose veins

A

Great saphenous

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5
Q

What does varicose veins lead to?

A

Progression, because valve incompetence and reflux
Vein segments below the defective valves distend and progressively fail as well

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6
Q

How do you get secondary varicosities?

A

May result from obstructive changes and valve damage in the deep venous system following thrombophlebitis
Rarely a result of proximal venous occlusion due to neoplasm or fibrosis
Can be due to congenital or acquired arteriovenous fistulas or venous malformations, especially if present in young patients

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7
Q

Classic clinical presentation of varicose veins

A

Standing up for long periods
Dull aching heaviness
Itching
Dilated tortuos veins
Chronic venous insufficiency (leading to ankle edema, brownish skin hyperpigmentation, and chronic skin induration of fibrosis)

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8
Q

Is severity of varicose veins have to do with severity of symptoms?

A

No

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9
Q

What can lead to induration and fibrosis?

A

Venous stasis, causing fibrotic hard skin leading to ulcerations

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10
Q

How to diagnose varicose veins?

A

Clinically

Only order imaging (venous duplex US) if you think there is an obstruction and need a surgery

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11
Q

Nonsurgical treatment of varicose veins and issues

A

Compression stockings (hoes)
Really hard to wear though

leg elevation above the heart (wedge pillows)

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12
Q

When should you use compression stocking

A

After you get up, because there is the least blood in your legs at that time

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13
Q

compression hoes order

A

the worse the symptoms, the higher the mmHg you order]

15-20 mmHg
20-30 mmHg
30-40 mmHg
40-50 mmHg
50 mmHg

custom fit

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14
Q

If a patient does not want to use compression stockings, what is a permanent option?

A

Sclerotherapy, endovenous laser therapy (EVLA), Endovenous Radiofrequency Ablation (EVRFA), vein stripping (last resort)

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15
Q

sclerotherapy procedure

A

Direct injection of a sclerosing agent¹ → permanent fibrosis and obliteration of the target veins
Recurrence rate is >50% if underlying reflux is not managed

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16
Q

Endovenous laser therapy procedure

A

Performed with local anesthesia
The laser heats up the small vein and destroys it
Could result in heat-induced thrombosis, requiring prolonged anticoagulation

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17
Q

Endovenous Radiofrequency Ablation (EVRFA) procedure

A

Better for significant varicose veins with signs of venous insufficiency or for long varicosities

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18
Q

Vein stripping

A

Involves removing the part of the vein that is torturous

LAST resort

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19
Q

What causes chronic venous insufficiency

A

Complication of varicose veins, DVT, injury, or something else

venous hypertension

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20
Q

What does chronic venous insufficiency look like?

A

Edema, (brawny) skin hyperpigmentation, subcutaneous lipodermatosclerosis in the lower leg
Venous ulcers characterized by ulcerations at or above the medial ankle

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21
Q

What is a complicating factor of chronic venous insufficiency

A

Obesity

leads to lower activity and further problems

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22
Q

Etiology of chronic venous insufficiency

A

Insufficiency → valve leaflets do not close because they are thickened and scarred (post-thrombotic syndrome) or are functionally inadequate due to vein dilation
Chronic thrombus/scarring causes proximal venous obstruction, worsening the problem
Venous reflux ensues leading to blood back up in the lower leg/foot
The leg develops venous hypertension and an abnormally high hydrostatic force is transmitted to the subcutaneous veins and tissues of the lower leg
The result is edema

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23
Q

what to order if you think there might be heart failure instead of chronic venous insufficiency

A

BNP

r/o CHF if <100

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24
Q

What are the pathologic changes of chronic venous insufficiency

A

Muscle biopsy demonstrates interstitial space changes
Enlargement and fibrosis
High levels of fibrinogen and fibrin
Edema and inflammation
Leads to local hypoxia and malnutrition
Increase in the number of capillaries in the subcutaneous tissue
Peri-capillary fibrosis
Manifested as subcutaneous thickening and induration
Hemosiderin deposits resulting from erythrocyte lysis

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25
Clinical manifestations of chronic venous insufficiency
Primary symptom: progressive pitting edema of the lower leg Secondary changes in the skin and subcutaneous tissues develop over time Stasis dermatitis Other common symptoms are itching, a dull discomfort made worse by periods of standing, and pain if an ulceration is present Secondary lymphedema can occur Progressive sclerosis of lymph channels Taut, shiny skin at the ankle due to edema Brownish skin pigmentation Also known as hemosiderin staining Eventual loss of skin integrity with ulceration Can develop secondary cellulitis aggravating the process Diagnosed by blanching erythema with pain Can eventually have relative fixation of the ankle joint secondary to tissue fibrosis
26
What is stasis dermatitis presentation
antibiotics from prescriber thinking it was cellulitis, except there is no pain, no recovery, not hot to touch also bilateral crusty, friable
27
where do you see hemosiderin staining
permanent discolation near the medial malleolus
28
Lipodermatosclerosis
manifestation of chronic venous insufficiency It is a type of panniculitis Affected legs typically have the following characteristics: Skin induration Increased pigmentation Swelling Redness “Inverted champagne bottle” or “bowling pin” appearance
29
Atrophie Blanche
white star deformities from decreased capillary blood flow to tissue Star-shaped or polyangular, ivory-white depressed atrophic plaques Prominent red dots within the scar due to enlarged capillary blood vessels Surrounding hyperpigmentation
30
spider veins under you medial malleolus
Corona Phlebectatica Characterized by abnormally dilated veins around the ankle
31
how to know if an ulcer is venous or arterial?
arterial lesions have well-defined borders (skin is warm, has pulses) venous lesions do not have well-defined borders (worse pulses)
32
How is chronic venous insufficiency diagnosed?
Clinically Duplex ultrasonography is the test of choice for planning therapy
33
Multidetector computed tomographic (MDCT) venography and magnetic resonance (MR) venography could be considered
Used if doppler US nondiagnostic Requires injection of IV dye $$ for chronic venous insufficiency
34
Mainstay treatment of chronic venous insufficiency
Same as vericose veins compression stockings during day or evening first line pneumatic compression if severe
35
Unna Boot
Paste gauze compression dressing for chronic venous insufficiency prescribed by wound care takes FORVER to do allows venous blood to compress back up to
36
What can happen if you do not take care of an underlying ulcer formation after removal of an Unna boot
It can come back
37
What can an IV lead to?
Superficial Venous Thrombophlebitis (inflammation)
38
Essentials of diagnosis of Superficial Venous Thrombophlebitis
Red, painful induration along a superficial vein Commonly occurs at the site of a recent IV line Marked swelling of the extremity may occur
39
Definition of Superficial Venous Thrombophlebitis
inflammation of a superficial vein, which typically results in a clot
40
Where is the clinical presentation of superficial venous thrombophlebitis
inflammation of a superficial vein, which typically results in a clot
41
complications of superficial venous thrombophlebitis
Complications in superficial thrombophlebitis: Extension into the deep venous system Hyperpigmentation over the affected vein Persistent, firm nodule in subcutaneous tissues at the site of the affected vein Conversion to suppurative thrombophlebitis
42
supportive thrombophlebitis
fluid and blood goes out of opening Metastatic abscess formation Septicemia Septic emboli not good to have
43
Superficial Venous Thrombophlebitis diagnosis
clinically WBC is elevated, but does not help change treatment Venous doppler ultrasound ONLY if involves the proximal lower extremity or if patient has mixed picture
44
management of mild Superficial Venous Thrombophlebitis
Mild, localized disease → mild analgesics, such as aspirin or NSAIDs, and the use of some type of elastic support usually are sufficient Patients are encouraged to continue their usual daily activities
45
Management of severe Superficial Venous Thrombophlebitis (>5 cm)
More severe, larger, associated with pain and redness → elevate the extremity and apply massive, hot, wet compresses 5 cm or longer → prophylactic dose Fondaparinux (Arixtra), LMWH, or Rivaroxaban (Xarelto) x 45 days Rapidly progressing disease or extension into deep system → full dose anticoagulation
46
Superficial Venous Thrombophlebitis with a cannula or catheter
removed and the device is cultured
47
if a patient is septic from Superficial Venous Thrombophlebitis, what do you do?
Vancomycin + Ceftriaxone Urgent treatment with Heparin or Arixtra
48
Prognosis of Superficial Venous Thrombophlebitis
Overall prognosis for most patients is good, as it is usually self-limiting, benign, and brief If associated with septicemia, mortality rate is 20% or more
49
Lymphangitis
Red streaking from wound or cellulitis towards regional lymph nodes, which are typically enlarged and tender Chills, fever, malaise may be present
50
overview of lymphangitis
Inflammation of the lymphatic channels May be infectious or noninfectious Lymphatic system function → resorb fluid and protein from tissues and extravascular spaces Lymphatic channels are situated in the deep dermis and subdermal tissues parallel to the veins and have a series of valves to ensure one-way flow it is the garbage truck
51
What does lymphangitis arise from and lead to
hemolytic streptococci or S. aureus red skin streaking extending proximally
52
Wuchereria bancrofti 
filarial nematode that is a major cause of acute lymphangitis worldwide; leads to a chronic Filariasis resulting in subsequent lymphedema with thickening of skin and subcutaneous tissue
53
Is lymphangitis reversible?
Not really :(
54
Nodular lymphangitis
→ painful or painless nodular subcutaneous swellings along the course of the lymphatic channels
55
What can you do if an open infection looks abnormal?
culture it
56
CC of lymphangitis?
malignancy
57
What is the classic clinical presenatation of lymphadentis
distal abrasian and follwing the streak up you see the lymph node
58
Diagnostic and eval of lymphangitis
CBC w/ diff and blood cultures must be obtained Wound culture, abscess I&D if possible Consider involving infectious disease to assist in the diagnostic workup Imaging may be helpful for defining anatomic abnormalities → rarely useful for diagnosis of infectious etiologies Lymphangiography and lymphoscintigraphy have been used to evaluate for lymphedema and/or lymphatic obstruction (inject dye into lymph system and see what happens)
59
Treatment of lymphagitis
covering for GABHS Keflex is common
60
Oral outpatient therapy
for patients who appear nontoxic, are afebrile, and not immunocompromised
61
symptomatic management of lymphangitis
Analgesics and/or anti-inflammatories for pain Can also help reduce inflammation and swelling Hot, moist compresses also help to reduce inflammation and pain Elevate and immobilize affected areas to reduce swelling, pain, and the spread of infection if possible An abscess may require surgical drainage Nodular lymphangitis often require surgical intervention
62
Lymphedema essentials of diagnosis
PAINLESS persistent edema of one or both lower extremities, primarily in young women PITTING edema w/o ulceration, varicosities, or stasis pigmentation Lymphangitis and cellulitis may develop
63
two types of lymphedema
Congenital (lymph vessels are over or under developed) Secondary damage: involves inflammatory or mechanical lymphatic obstruction from trauma, regional lymph node resection/irradiation, or malignant disease or filariasis May occur following surgical removal of the lymph nodes in the groin or axilla
64
What leads to secondary dilation of lymphedema
can occur in both forms → leads to incompetence of the valve system, poor lymphatic fluid flow, and results in progressive stasis of a protein-rich fluid Can result in episodes of acute and chronic inflammation, worsening the edema
65
What makes lymphedma different from others
PAINLESS mainly leads to unsightly and trouble with ADLs
66
Treatment of lymphedema
No cure for lymphedema (LIFELONG): Treatment aimed at controlling lymphedema and allowing normal function Common treatment strategies Edema control Intermittent leg elevation, especially while sleeping (foot of bed elevated 15–20 degrees) Constant use of graduated elastic compression stockings Massage toward the trunk (either by hand or with pneumatic pressure devices designed to “milk” edema out of an extremity”) Common treatment strategies Referral to wound care centers Stress good hygiene and treatment of any secondary infection Intermittent use of diuretics therapy is rarely helpful Amputation is used only for the rare complication of lymphangiosarcoma in the extremity
67
do diuertics work on lymph vessels?
No :( which is why it cannot be used for lymphedema