peripheral vascular disease Flashcards

1
Q

PVD

A

umbrella term used to describe several circulatory diseases

only called PAD when arteries are involved

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2
Q

pathophysiology of PVD

A

related to atherosclerosis processes in the extremities
lower ext. atherosclerosis
ischemia reperfusion of calf skeletal muscle
reduced myofibers in calf muscle, impaired mitochondria, muscle damage, impaired peripheral nerve function
impaired oxygenation
reduced leg strength
poor 6 min walk
increased rates of mobility loss

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3
Q

risk factors for PVD

A

smoking, high cholesterol, stroke, diabetes, heart disease, increased age >50

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4
Q

causes of PVD

A

atherosclerosis- most common cause
thrombus
inflammation- thromboangitis
vasospasm- Raynaud’s disease or an autoimmune disease

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5
Q

clinical manifestations of PVD

A
dull achy pain in legs
lower leg edema
pulse present
drainage
sores with irregular borders
yellow slough or ruddy skin
thick toenails
sore on ankles
tired/heavy legs
pain WORSENS when standing and IMPROVES with elevation and activity
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6
Q

what is intermittent claudication?

A

cramping pain of lower extremity or buttock caused by atrial flow obstruction
STOPS WITH REST
caused by ischemic tissue
pain depends on site of plaque build up, collateral circulation

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7
Q

common site for PAD

A

femoral artery

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8
Q

causes of PAD

A
lack of circulation
pain
decreased pulse
coolness of leg
pallor of leg
loss of sensation in foot
ischemia of muscle in lower leg, cellular hypoxia
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9
Q

5 p’s of PVD

A
pain (intermittent caludication)
pulselessness
palpable coolness
parasthesias
paresis (weakness of extremity)
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10
Q

how do you diagnose PVD

A

ankle-brachial index

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11
Q

ankle-brachial index (ABI)

A

comparison of blood pressure in leg vs. arm
normal ratio is greater than 1
normal= ankle pressure is greater than brachial pressure

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12
Q

a ABI of 1-1.4

A

normal

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13
Q

a ABI of 0.9-1.0

A

acceptable

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14
Q

a ABI of 0.8-0.9

A

some arterial disease

treat risk factors

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15
Q

a ABI of 0.5-0.8

A

moderate arterial disease, refer to vascular specialist

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16
Q

ABI less than 0.5

A

severe arterial disease, refer to vascular specialist

17
Q

clinical manifestations of PAD

A
intermittent claudication pain
no edema
no pulse or weak pulse
no drainage
round smooth sores
black eschar
sores on toes and feet
cramping pain, tired leg and hip muscles that WORSENS with activity and subsides with rest
18
Q

treatment of PAD

A

antiplatelet (clopidogrel)

surgical: fempop bypass

19
Q

what causes PAD

A

narrowing or arteries, commonly in pelvis and legs

20
Q

what is chronic venous insufficiency? (CVI)

A

occurs when venous walls and/or valves in leg VEINS are not working effectively
causes blood to pool or collect in the veins (venous stasis)
chronic

21
Q

symptoms of venous insufficiency

A
lower extremity edema
achiness or tiredness in legs 
leathery looking skin
stasis ulcers
flaking or itching skin
new varicose veins
22
Q

nonpharmacological treatment of PVD

A
reduction of contributing factors
smoking cessation
increase physical activity
weight reduction
stress reduction
DM management
HTN control
23
Q

pharmacological tx of PVD

A

antiplatelet agents
anticoags
thrombolytics
lipid lowering agents

24
Q

cilostazol (pletal)

A

used for intermittent claudication

platelet inhibitor, vasodilation

25
Q

side effects of cilostazol

A

ha, dizziness, diarrhea, abnormal stools, palpitations, peripheral edema

26
Q

drug interactions with cilostazol

A

metabolized by cytochrome P450

27
Q

pentoxifylline/trental

A

vasoactive agent
used to treat intermittent claudication caused by PVD
relieves leg pain by increasing blood flow and oxygen through blood vessels.
help increase walking distance an duration
PO TID

28
Q

adverse reactions of pentoxifylline/trental

A

n/v, dizziness