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@N MEDICINE > PERIPHERAL NEUROPATHY > Flashcards

PERIPHERAL NEUROPATHY Flashcards

1
Q

Tinel sign

A

Tingling and pain on tapping flexor aspect of wrist
Seen in CARPAL TUNNEL SYNDROME

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2
Q

Phalens test

A

Increased pain and tingling on passive maximal flexion of wrist

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3
Q

Clinical features of. carpal tunnel syndrome

A

Nocturnal pain
Parasthesia and tingling on palmar aspect of hand or wrist

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4
Q

Causes of Carpal tunnel syndrome/ ENTRAPMENT NEUROPATHY

A

Hypothyroidism
Diabetes mellitus
Amyloidosis
Systemic sclerosis
Rheumatoid arthiritis
SLE
Acromegaly
3 Rd trimester of pregnancy

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5
Q

Causes of Mononueritis multiplex 🌟 WA²RDS P²LC³

A

Wegener’s Granulomatosis
Amyloidosis
AIDS
RA
DM
SARCOIDOSIS
PAN
Paraneoplastic syndrome
Leprosy (most common cause)
Cancer
Churg Strauss
Hepatitis C

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6
Q

Causes of mononeuroparhy

A

Acute ; sustained pressure , torniquet
Chronic : entrapment syndrome

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7
Q

Nerve involved in carpal tunnel syndrome

A

Median nerve

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8
Q

Nerve involved in cubital tunnel syndrome

A

Ulnar nerve

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9
Q

Nerve involved in spiral groove of humerus

A

Radial nerve

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10
Q

Nerve involved in inguinal ligament

A

Lateral cutaneous nerve of thigh
MERALGIA PARASTHETICA

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11
Q

Nerve involved in neck of fibula

A

Common peroneal nerve

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12
Q

Nerve involved in Tarsal tunnel syndrome / flexor retinaculum

A

Posterior tibial nerve

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13
Q

Causes of polyneuropathy 🌟 VITS OMG

A

Vitamin deficiency
Infection
Inflammation
Therapeutic drugs
Toxins
Systemic
Other
Malignancy
Genetics

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14
Q

Causes of polyneuropathy: Vitamin deficiency

A

Vitamin B 12
Thiamine
Pyridoxine
Vitamin E

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15
Q

Causes of polyneuropathy: therapeutic drugs

A

Amiodarone
Antibiotics - isoniazid , ethambutol, metronidazole, dapsone
Phenytoin
Chemotherapy - Cisplatin , vincristine , thalidomide

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16
Q

Causes of polyneuropathy: TOXINS

A

Alcohol
Nitrous oxide

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17
Q

Causes of polyneuropathy: Inflammation

A

GBS
VASCULITIS ( PAN, SLE )
PARANEOPLASTIC SYNDROME

18
Q

Causes of polyneuropathy: systemic

A

Diabetes
Renal failure

19
Q

Causes of polyneuropathy: malignancy

A

Infiltration

20
Q

Causes of polyneuropathy: genetic dis

A

CMTD ( charcot Marie tooth disease)
Familial amyloid polyneuropathy
Hereditary neuralgic amyotrophy

21
Q

Causes of polyneuropathy: others

A

Paraproteinemia
Amyloid

22
Q

Drugs causing peripheral neuropathy 🌟 MANIC PVC

A

Metronidazole
Amiodarone
Nitrofurantoin
Isoniazid
Cis platin
Phenytoin
Vinca alkaloids
Ciprofloxacin

23
Q

Causes of Demyelinating polyneuropathy

A

CIDP
PADP
CMTD X
MND

Chronic inflammatory Demyelinating polyneuropathy
Paraprotein associated Demyelinating polyneuropathy
Charcot Marie tooth disease type x
Motor neuron disease

24
Q

Causes of axonal polyneuropathy

A

Diabetes
Hypothyroidism
Rheumatoid arthiritis
SLE
Systemic sclerosis
SJOGRENS
Alcohol
Uremia
Cirrhosis
PARANEOPLASTIC
Deficiency - B1, B6, B12 , vit e
Genetic - CMTD type 2
Idiopathic
Hereditary
Drugs and toxins

25
Q

Causes of Peripheral Nerve thickening 🌟 LANDS CAR

A

Leprosy - most common cause
Amyloidosis
Neurofibromatosis
DM
SARCOIDOSIS

CIDP
CMTD
Acromegaly
ReFSUM disease
Relapsing GBS

26
Q

Acute onset polyneuropathy

A

MCC - viral infectious ( influenza , cmv , hep B , EBV
GBS- campylobacter jejunii
AIP PORPHYRIA
ARSENIC / THALLIUM TOXICITY
DM

27
Q

Sub acute onset polyneuropathy

A

Toxins medication
Nutritional def
Metabolic
PARANEOPLASTIC

28
Q

Chronic polyneuropathy

A

CIDP
CLD
HMSN ( hereditary motor and sensory NEUROPATHY)

29
Q

Causes of Relapsing / remitting polyneuropathy

A

GBS
Aids
Prophyria
CIDP

30
Q

Causes of Pure motor neuropathy 🌟 PHD is A TALL degree

A

Poliomyelitis
Hereditary spinal muscular atrophy
Dapsone intoxication
Adult form of hexosaminidase deficiency
Tick bite paralysis
AIP
Lead intoxication
Lambert Eaton syndrome
Lmn form of ALS
Brachial neuritis
Diptheria
MND

31
Q

Neuropathy involving small muscles of hand

A

CIDP
MND
LEAD intoxication
THALLIUM TOXICITY
Polio late stages
Leprosy

32
Q

In early stages peripheral neuropathy is - Distal / proximal

A

Ans - Distal
Exception - CIDP is characterised by Proximal muscle weakness in early stages ( Demyelinating polyneuropathy)
Also AIP

33
Q

Motor symptoms +/-

A

Postive - cramps
Fasciculation
Spasm
Tremor

Negative - weakness
Wasting
Loss of dexterity ( handedness)

34
Q

Sensory symptoms

A

Positive - Tingling
Burning
Pain
Needles
Band like
Stumbling

Negative - numbness , loss of sensation

35
Q

Allodynia

A

Highly painful sensation to non noxious stimuli

36
Q

Cause of small fibre neuropathy

A

Diabetes
Amyloidosis
Hypothyroidism
Fabrys disease
Hiv
SJOGRENS syndrome
Cis platin
Amiodarone
THALLIUM TOXICITY
ARSENIC toxicity

37
Q

Causes of Large fibre neuropathy

A

SJOGRENS
Vit b12
Cisplatin
DM
Amyloid
Lead intoxication
Friedrichs ataxia
B6 toxicity
Hiv

38
Q

Peripheral NEUROPATHY ass with pain

A

Cyptogrnic sensorimotor NEUROPATHY
DM
ARSENIC THALLIUM TOXICITY
GBS
VASCULITIS
HIV
FABRYS

39
Q

Signs and symptoms ass with ANS NEUROPATHY

A

Bradycardia
Tachycardia
Perspiration
Urine retention
Postural hypotension
Psvt
BP
Bowel bladder sexual dysfunction

40
Q

NEUROPATHY ass with autonomic signs

A

Acute - botulism
PORPHYRIA
GBS
Amiodarone
Vincristine

Chronic - DM
SJOGRENS
CHAGAS
AMYLOID
PNS

41
Q

Approach to a patient with neuropathy 🌟 6 Ds

A

Duration
Distribution
Deficit
Disease pathology
Developmental / inherited
Drug / toxins exposure

@N MEDICINE (9 decks)

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