Peripheral Neuropathies Flashcards
Name some conditions that result in SENSORY peripheral neuropathies?
Diabetes Thiamine deficiency Malignancy Leprosy Hereditary sensory neuropathies; Charcot Marie-Tooth Amyloid Uraemia
Name some conditions that result in MOTOR peripheral neuropathies?
Guillain–Barré syndrome Porphyria Diphtheria Botulism Lead toxity Charcot–Marie–Tooth disease
How do sensory peripheral neuropathies present?
Tingling
Numbness
Insensitive to pain and temperature
Extreme sensitivity to pain/touch
How do motor peripheral neuropathies present?
twitching and muscle cramps.
muscle weakness or paralysis affecting one or more muscles.
thinning (wasting) of muscles.
difficulty lifting up the front part of your foot and toes, particularly noticeable when walking (foot drop
what are the underlying pathophysiologiogy of peripehral neuropathies?
- Axonal - most common
- seen in systemic, metabolic, toxic, and nutritional disorders
- Long large diameter fibres
- eg CMT1
- Demyelinating
- eg GBS, CMTooth2
How do we ivx P Neuropathies?
Nerve conduction studies - axonal or demyelinating
EMG - can differentiate if acute or chronic
Bloods; metabolic causes
Urine tests - toxins and poisons
Genetic test eg in CMT
symptoms of autonomic neuropathy?
Postural hypotension: lightheadedness, dizziness, fainting, dimness of vision, unsteady gait, weakness
Urinary dysfunction: frequency, excessive urinating at night, urgency, stress incontinence, retention, hesitancy
Sexual dysfunction: erectile dysfunction, vaginal dryness, decreased libido
GI dysfunction: intermittent diarrhea, constipation, nausea, vomiting, full-ness after eating little, loss of appetite, slowing of gastric content, bloating, heartburn
Impaired sweating: excessive or decreased sweating
Exercise intolerance
presentation of sensory peripheral neuropathy?
glove and stocking distribution
