Peripheral neurology

Question 1

Differentials for a symmetrical lower motor peripheral neuropathy with normal sensation

Answer 1

GBS
Chronic inflammatory demyelinating polyradiculoneuropathy
Motor neurone disease

Question 2

Causes of proximal weakness

Answer 2

Muscular dystrophy
GBS
CIDP
Metabolic/endocrine: hypothyroid, Mcardle, maltase deficiency
Alcohol/statins
MG
Lambert-Eaton

Question 3

Sensory-motor peripheral neuropathy: causes

Answer 3

Endocrine: Diabetes; B12/folate deficiency; hypothyroid
Drugs: alcohol; anti-tb; antibiotics; anti-cancer; anti-arhythmia; anti-epileptic
Hereditary: HSMN
Infections: leprosy, HIV, syphilis

Question 4

Mainly MOTOR neuropathy:

Answer 4

GBS
CIDP
multifocal motor neuropathy with conduction block
Diabetic amyotrophy
Only motor: Lead poisoning; Acute intermittent porphyria

Differentials: NMJ problem and muscular dystrophy or MND

Question 5

Sensory neuropathy

Answer 5

Paraneoplastic syndrome
Sjogrens
Friedrich ataxia
Drugs

Question 6

Causes of mononeuritis multiplex

Answer 6

Primary vasculitis: Churg-Struass, wegeners, polyarteitis nodosa; microscopic polyangitis
Secondary vasculitis: RA, SLE, hep B/C, cryoglobulinarmias
Sjogrens
Sarcoidosis
Hep C

Question 7

Causes of a peripheral neuropathy

Answer 7

Metabolic causes: diabetes, hypothyroidism, b12, folate, alcohol, lead
Hereditary: HSMN, freidrichs ataxia
Inflammatory: GBS, CIPD
Infectious: Lyme, leprosy, HIV
Amyloid, sarcoidosis, Polyarteritis nodosa, paraneoplastic