Myasthenia Gravis Flashcards
1
Q
What is myasthenia gravis?
A
Autoimmune condition
Antibodies against nicotinic acetylcholine receptor antibodies at the neuromuscular junction
2
Q
Examination routine
A
Bilateral ptosis
Complex ophthalmoplegia
Dysphonia/Dysarthria/Dysphagia
Proximal muscle weakness with fatiguability
Normal reflexes
Examine the neck for goitre/thymus
3
Q
Investigations for MG
A
TFTs
Anti-AChR
Anti-muscle-specific kinase
EMG
CT/MRI of the mediastinum for thymoma
4
Q
What are the causes of bilateral ptosis
A
MG
Myotonic dystrophy
Kearn’s-sayre
bilateral horners
5
Q
Causes of complex ophthalmoplegia
A
MG
Graves
Miller-fisher (variant of GBS)
Keener’s-Sayers
6
Q
Management
A
manage underlying malignancy
FVC monitoring
Immunoglobulins
plasmapheresis
chronic:steroids/azathioprine
manage dysphagia
