Peripheral Nervous System Tissue Flashcards
Neuron definition
Cells that respond to stimuli by altering the ionic gradient across their plasma membranes. Functional units of both the CNS and PNS.
Three main parts of neurons
Cell body (soma), dendrites and axon
Cell body function
contains nucleus and most of the cell’s organelles and serves as as the synthetic or trophic centre for the entire neuron
Cell body components
Numerous free polyribosomes and highly developed RER, indicating active production of cytoskeletal proteins for transport and secretion. Basophilic Nissl polysomes appear under a light microscope. Golgi apparatus, located in cell body, mitochondria found throughout the cell.
Dendrite function
principle signal reception and processing sites on the neurons. conduct electrical impulses to cell body.
Dendrite structure
Short branched projections leading to the cell body. Thinner dendritic processes as they bench, with cytoskeletal elements predominating in the distal regions.
Dendritic spine function
Most synapses on dendrites in the CNS occur at the dendritic spines, which are dynamic membrane protrusions on the dendritic branches.
What sort of structures are dendritic spines?
Plastic, as they change morphology depending on actin filaments (neural plasticity)
What is neural plasticity involved in?
Underlies adaptation, learning and memory development
What are axons?
Long slender projections that arise from the cell body and conduct electrical impulses away from the soma to other cells
Axon structure
Very long process, that can be up to a metre in length. Plasma membrane of the axon is called the axolemma and its contents are the axoplasm.
Where does the axon originate from?
The Axon hillock on the soma
What is terminal aborisation?
Axons have small branches called collaterals, which each end with an axon terminal (terminal bouton). This contacts another neutron at a synapse to initiate an impulse in that cell.
What do axons lack and how is this overcome?
Axons lack a protein synthesis machinery, so all the organelles and proteins required by the axon (neurotransmitters) must be transported from the cell body after synthesis.
Anterograde transport and the microtubule involved
Movement away from the cell body, kinesin
Retrograde transport and the microtubule involved
Movement along dynein towards the soma.
What is transported via anterograde transport?
organelles and macromolecules synthesised by the cell body
What is transported via retrograde transport?
Materials taken up by endocytosis, including viruses and toxins
Two types of polarity exhibited by neurons
Structural and functional
Explain structural polarity
One end of the neurone specialised to receive impulses (dendrites contain neurotransmitter receptors at synapses) the other end is specialised to send signals (axon terminals contain vesicles with acetylcholine)