periodontal pathogens Flashcards

1
Q

how can pathogens overcome host defenses?

A

1) Desquamation of epithelium
2) Antibody prevent binding
3) Phagocytic cells

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2
Q

what are the 3 “designated pathogens” discovered in 1996?

A

P.gingivalis

A.actinomycetemcomitans

T.forsythia

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3
Q

virulence factors of A.a

A
Tissue invasive- epithelial and endothelial cells
Leukotoxin 
Fibroblast inhibiting factor
Endotoxin
Collagenase
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4
Q

t/f: A.actinomycetemcomitans inhibits the growth of commensal species, such as Streptococcus sanguis

A

true

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5
Q

which A.a Serotype is most commonly associated with localized aggressive periodontitis in USA?

A

serotype B

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6
Q

t/f: Lipoteichoic acid is a virulence factor produced by A.a

A

FALSE

Lipoteichoic acid is only produced by gram positive bacteria

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7
Q

what bacteria produce collagenase, proteases,hemolysins, endotoxin, fatty acids, NH3, H2S and indole

A

Porphyromonas gingivalis

P. gingivalis

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8
Q

P. gingivalis produces __________, which is important in protein degradation and in the maturation of cell surface proteins such as fimA fimbrillin

A

Cysteine proteinases (ARG-gingipain and LYS-gingipain)

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9
Q

T/F: P. gingivalis is not seen in healthy patients, but is also not always seen in disease

A

FALSE

Seen in health
Not always seen in disease

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10
Q

which oral pathogen requires N-acetylmuramic acid (NAM) to grow?

A

Tannerella forsythia

T. forsythia

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11
Q

T. forsythia Co-cultivates with _________

A

F.nucleatum

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12
Q

what is the function of the Serrated S-layer on cell surface

of T. forsythia?

A

Mediates adhesion

Hemagglutination

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13
Q

_________ are highly motile microorganisms who inhabit the oral cavity

A

Spirochetes

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14
Q

which oral microbe is associated with puberty/ pregnancy gingivitis?

A

Prevotella intermedia/nigrescens

P. intermedia

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15
Q

_________ is the most common isolate cultured from subgingival microbiota in health and disease

A

Fusobacterium nucleatum

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16
Q

what virulence factors does F. nucleatum release?

A

Releases cytokines, elastase and oxygen radical from leukocytes.