periodontal pathogens Flashcards
how can pathogens overcome host defenses?
1) Desquamation of epithelium
2) Antibody prevent binding
3) Phagocytic cells
what are the 3 “designated pathogens” discovered in 1996?
P.gingivalis
A.actinomycetemcomitans
T.forsythia
virulence factors of A.a
Tissue invasive- epithelial and endothelial cells Leukotoxin Fibroblast inhibiting factor Endotoxin Collagenase
t/f: A.actinomycetemcomitans inhibits the growth of commensal species, such as Streptococcus sanguis
true
which A.a Serotype is most commonly associated with localized aggressive periodontitis in USA?
serotype B
t/f: Lipoteichoic acid is a virulence factor produced by A.a
FALSE
Lipoteichoic acid is only produced by gram positive bacteria
what bacteria produce collagenase, proteases,hemolysins, endotoxin, fatty acids, NH3, H2S and indole
Porphyromonas gingivalis
P. gingivalis
P. gingivalis produces __________, which is important in protein degradation and in the maturation of cell surface proteins such as fimA fimbrillin
Cysteine proteinases (ARG-gingipain and LYS-gingipain)
T/F: P. gingivalis is not seen in healthy patients, but is also not always seen in disease
FALSE
Seen in health
Not always seen in disease
which oral pathogen requires N-acetylmuramic acid (NAM) to grow?
Tannerella forsythia
T. forsythia
T. forsythia Co-cultivates with _________
F.nucleatum
what is the function of the Serrated S-layer on cell surface
of T. forsythia?
Mediates adhesion
Hemagglutination
_________ are highly motile microorganisms who inhabit the oral cavity
Spirochetes
which oral microbe is associated with puberty/ pregnancy gingivitis?
Prevotella intermedia/nigrescens
P. intermedia
_________ is the most common isolate cultured from subgingival microbiota in health and disease
Fusobacterium nucleatum