Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

BDS3 Microbiology and Oral Pathology > Periodontal Microbiology > Flashcards

Periodontal Microbiology Flashcards

You may prefer our related Brainscape-certified flashcards:
Biology 101 flashcards
1
Q

what factors influence the oral microflora

A

host factors
diet
saliva
gingival crevicular fluid
microbial interactions
gaseous environment

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

what are the classifications of periodontal disease

A

gingivitis
periodontitis - chronic or aggressive
necrotising periodontitis
peri-implantitis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

what host factors can influence the start of periodontal disease

A

smoking
genetics
pregnancy
systemic disease
nutrition

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

how does periodontitis develop

A

high concentrations of periodontitis causing bacteria causes severe inflammation and pocket formation leading to degradation of soft and bone tissue

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

what bacteria can cause periodontal diseases

A

P. gingivalis
prevotella intermedia
AA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

describe P gingivalis

A

gram negative, non-motile rod, strict anaerobe

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

what are some virulence factors of P gingivalis

A

host cell tissue adherence and invasion
elaboration of proteases - leads to lots of degradative enzymes
endotoxins
capsular polysaccharide and outer membrane vesicles
tissue toxic metabolic by-products

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

what enables P gingivalis to adhenre and invade the host cell tissue

A

fimbriae

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

what are the cocktail of degradative enzymes associated with P gingivalis

A

collagenase
fibrinolysin
phospholipase A
phosphotases

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

what are the tissue toxic by-products of P gingivalis

A

hydrogen sulphide
ammonia
fatty acids

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

how do fimbrillar adhesins help invade host cells

A

bind to their cellular integrins

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

what are the two types of fimbriae

A

long (FimA) - inital attachment and biofilm organisation
short (Mfa1) - microcolony formation by cell to cell autoaggregation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

what is a biofilm

A

community of microbes attached to a surface

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

what are the development phases of biofilm formation

A

host salivary glycoproteins, linking fim
coaggregation, re-conditiong film, accumulation and shedding

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

what occurs to biofilm as disease moves from health the perio

A

the number and severity of pathogens increases

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

what are the stages in biofilm development

A

adhesion
colonisation
accumulation
complex community
dispersal

17
Q

what microorganisms may be associated with oral health

A

oral streptococci
fusobacterium

18
Q

what is Socransky’s model

A

relationship of species within microbial complexes

19
Q

how do microbes act competitively

A

metabolic products - acids, oxidants
bacteriocins
receptor antagonism

20
Q

how do microbe act co-operatively

A

metabolic products - saccharides, peptides, growth factors
adhesion substrates
immune avoidance

21
Q

what is the healthy plaque theory

A

if you modify the environment the healthy plaque can change to diseased

22
Q

give examples of changing a microbiome

A

broad scale antibiotics
chlorhexidine mouthwash

23
Q

what microorganism is very important for the aggregation of other pathogenic molecules

A

fusobacterium nucleatum

24
Q

what is Koch’s postulates

A

you would be able to isolate the disease and then entering it into an animal host and it would cause the disease you are investigating

25
Q

why is P gingivalis black pigmented

A

iron accumulation from hemin

26
Q

what are gingipains

A

a feature of P gingivalis that help them stick to places and help them to get nutrition - it releases MMPs so it can release nutrients from the degraded tissues

27
Q

what does AA produce that could play in periodontal disease

A

leukotoxin
cytotcin
LPS
Fc binding proteins
fimbriae
phase variation

28
Q

why is loss of attachment important to microbiomes also

A

it gives a new niche for the microbes to set up

29
Q

what are systemic complications of P. gingivalis or chronic inflammation in the mouth

A

produces proteins that are like autoantibodies and presence of rheumatoid arthritis and atherosclerotic plaques
plaque can travel in the systemic circulation and end up on prosthetics

30
Q

what is the clinical management of P. gingivalis

A

mechanical disruption - brushing
chemotherapeutic
surgery

31
Q

what could unknowingly cause an alteration to a patients biofilm

A

regular use of chlorhexidine mouthwash

32
Q

describe P gingivalis

A

gram negative
non-motile
rod
strict anaerobe

33
Q

what are virulence factors of p gingivalis

A

fimbrae
endodtoxins (LPS)
capsular polysaccharide and outer membrane vesicles

34
Q

what provides nutrition to p gingivalis

A

gingipains

35
Q

what aspect of p gingivalis has the potenital to tell host tissues to start destroying

A

MMPs

36
Q

what are systemic implications of periodontal microbes

A

risk of rheumatoid arthritis
increased CVD

BDS3 Microbiology and Oral Pathology (6 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions