Period of Serology

Question 1

Discovered blood group antigens

Answer 1

Landsteiner

Question 2

Father of immunohematology - He coined the term “haptens”

Answer 2

Landsteiner

Question 3

Complement fixation test

Answer 3

Bordet and Gengou (1901)

Question 4

Immediate-hypersensitivity Anaphylaxis

Answer 4

Portier, Richet (1902)

Question 5

Observed that the initial exposure of an antigen to an animal induces immunity, while a subsequent exposure to the same antigen triggers hypersensitivity reaction

Answer 5

Arthus (1903) - Arthus reaction of intermediate hypersensitivity

Question 6

Hypothesis of antigen-antibody binding (Lattice Formation)

Answer 6

Marrack (1938)

Question 7

Hypothesis of allograft rejection - although organs from human are expected to be compatible with other humans, this compatibility is often hindered by differences in tissue types.

Answer 7

Marrack (1944)

Question 8

Development of polio vaccine

Answer 8

Salk, Sabin (1949)

Question 9

Killed, inactivated vaccine (Do not provide immunity that is as strong as live vaccine).

Answer 9

Salk polio vaccine

Question 10

Live, attenuated vaccine (Weakened form of virus)

■ Stimulates better immune response, since they are similar to natural infection

Answer 10

Sabin polio vaccine

Question 11

Vaccine against yellow fever

Answer 11

Reed (1951)

Question 12

Graft-versus-host reaction

Answer 12

Reed (1953)

Question 13

Clonal selection theory

Answer 13

Burnet

Question 14

Interferon

Answer 14

Burnet
(1957)

Question 15

Human Leukocyte Antigens

Answer 15

Burnet (1958-1962)

Question 16

T-cell and B-cell cooperation in immune response

Answer 16

Burnet (1964-1968)

Question 17

Identification of Ab molecule

Answer 17

Edelman, Porter (1972)

Question 18

First monoclonal antibodies - use of cancer cells

Answer 18

Kohler (1975)

Question 19

Determined the existence of genes that control graft rejection

Answer 19

George snell (1980)

Question 20

Technique to identify molecules (HLAs) found on the surface of cells; thereby decreasing graft rejection

Answer 20

Jean Dausset (1980)

Question 21

● Inheritance of an animal’s ability to make antibodies to defined molecules

● Ability to respond to an antigen determining resistance and susceptibility

Answer 21

Baruj Benacerraf (1980)

Question 22

Identification of genes for T-cell “switches”receptor (TCR Gene)

Answer 22

1985-1987

Question 23

Monoclonal hepatitis B vaccine

Answer 23

1986

Question 24

Most common blood borne pathogen in healthcare workers

Answer 24

Hepatitis B Virus

Question 25

Th1 vs. Th2 model of T-helper cell function

Answer 25

Mosmann (1986)

Question 26

First organ transplantation from identical twins → kidney

Answer 26

Murray (1990)

Question 27

Bone marrow organ transplantation - utilized immune suppresants (immune suppressive drugs) to transplant bone marrow successfully

Answer 27

Thomas (1990)

Question 28

Identification of toll-like receptors

Answer 28

1996-1998

Question 29

FOXP3: gene directing regulatory T-cell development

Answer 29

2001

Question 30

Development of the human papillomavirus vaccine

Answer 30

Frazer (2005)