Early Immunology

Question 1

Contagion and germ theory of diseases

Answer 1

Girolamo Fracastoro

Question 2

Inducing immunity against smallpox using cowpox.

“Concept” that cowpox is less virulent than smallpox; thus, the less severe virus might protect individuals to a much severe virus, smallpox

Answer 2

Benjamin Jesty (1774)

Question 3

Created the first method of
stimulating the immune system without pathogenicity → cross-immunity

Answer 3

Edward Jenner (1798)

Question 4

Founder of immunology

Answer 4

Edward Jenner (1798)

Question 5

Live, attenuated chicken cholera and anthrax vaccine

Answer 5

Pasteur (1880-1881)

Question 6

Father of immunology

Coined the term “Vaccination”

Answer 6

Pasteur (1880-1881)

Question 7

Cellular immunity through phagocytosis

Answer 7

Metchnikoff 1883-1905

Question 8

Therapeutic Vaccination

First report of live “attenuated” vaccine for rabies (prophylactic)

Answer 8

Pasteur (1885)

Question 9

Humoral theory of immunity proposed

Answer 9

Von Behring, Kitasata (1890)

Question 10

Demonstration of cutaneous (delayed-type) hypersensitivity

Answer 10

Koch (1891)

Question 11

Passive immunization

Answer 11

Emil Roux (1894)

Question 12

Antibody Formation Theory - Developed the “side chain theory”

Answer 12

Ehrlich (1900)