Peptic Ulcer Disease Flashcards
What is peptic ulcer disease
Erosion of the gastric or duodenal ulcer extending into the submucosa or deeper
Which type of ulcer tends to be worse at night
Duodenal
What most commonly causes duodenal ulcers
H. Pylori
What most commonly causes gastric ulcers
NSAIDS
Where does H. Pylori tend to settle
In the antrum of the stomach
Describe the underlying pathogenesis of duodenal ulcers
H. Pylori in the antrum causes decreased somatostatin secretion and increased gatrin- more gastric acid
Describe the underlying pathogenesis of gastric ulcer
NSAIDS lead to reduced prostaglandins and reduced mucin
What is non-ulcer dyspepsia
Symptoms of dyspepsia but endoscopy shows no abnormalities or ulcers
How should non-ulcer dyspepsia be managed
Improves with time and treatment of the symptoms (PPI)
What investigations should be done
- Urea breath test/ stool antibody test
- FBC
- Endoscopy is aged over 55/ red flag symptoms
When would a barium swallow be used
When the patient can’t tolerate an endoscopy
How are peptic ulcers treated
Triple therapy if H. Pylori detected
Name some complications of peptic ulcers
Perforation
GI bleeds
Gastric outlet obstruction
Describe the action of H. Pylori in the production of excess acid
- Produces ammonia to neutralise acidity
- Lives in crypts next to acidic centres of stomach acid
- Excess acid produced
What would board like rigidity suggest
Perforation