Peptic Ulcer Disease Flashcards

1
Q

What is peptic ulcer disease

A

Erosion of the gastric or duodenal ulcer extending into the submucosa or deeper

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2
Q

Which type of ulcer tends to be worse at night

A

Duodenal

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3
Q

What most commonly causes duodenal ulcers

A

H. Pylori

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4
Q

What most commonly causes gastric ulcers

A

NSAIDS

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5
Q

Where does H. Pylori tend to settle

A

In the antrum of the stomach

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6
Q

Describe the underlying pathogenesis of duodenal ulcers

A

H. Pylori in the antrum causes decreased somatostatin secretion and increased gatrin- more gastric acid

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7
Q

Describe the underlying pathogenesis of gastric ulcer

A

NSAIDS lead to reduced prostaglandins and reduced mucin

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8
Q

What is non-ulcer dyspepsia

A

Symptoms of dyspepsia but endoscopy shows no abnormalities or ulcers

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9
Q

How should non-ulcer dyspepsia be managed

A

Improves with time and treatment of the symptoms (PPI)

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10
Q

What investigations should be done

A
  • Urea breath test/ stool antibody test
  • FBC
  • Endoscopy is aged over 55/ red flag symptoms
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11
Q

When would a barium swallow be used

A

When the patient can’t tolerate an endoscopy

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12
Q

How are peptic ulcers treated

A

Triple therapy if H. Pylori detected

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13
Q

Name some complications of peptic ulcers

A

Perforation
GI bleeds
Gastric outlet obstruction

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14
Q

Describe the action of H. Pylori in the production of excess acid

A
  • Produces ammonia to neutralise acidity
  • Lives in crypts next to acidic centres of stomach acid
  • Excess acid produced
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15
Q

What would board like rigidity suggest

A

Perforation

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16
Q

What is seen on a CT abdomen if a perforation has occured

A

Air under the diaphragm

17
Q

Do men or women get ulcers more

A

M

18
Q

What is the most common site of duodenal ulcer perforation

A

Anterior duodenum

19
Q

Describe the classic presentation of a patient with a perforated peptic ulcer

A
  • Severe pain, beginning epigastric and becoming localised
  • Shock
  • Peritonitis
20
Q

What is the immediate action when a patient presents with a perforated peptic ulcer

A

’ Drip and suck ‘

  • IV fluids
  • NG tube to empty the stomach
21
Q

Describe the surgical repair used for a perforated peptic ulcer

A

Peritoneal washout and surgical repair with a patch of omentum

22
Q

Are gastric or duodenal ulcers likely to be/ become malignant

A

GASTRIC