Peptic Ulcer Disease

Question 1

Main causes of peptic ulcer disease

Answer 1

NSAIDS
H. Pylori
Smoking, Alcohol
Bile Acids, Steroids, Stress, Pepsin

Question 2

Relationship between H. Pylori, Smoking & NSAIDS

Answer 2

H. Pylori - Causes chronic gastritis

NSAIDS - COX1 inhib - inhibits prostaglandin secretion

Question 3

Symptoms of Peptic Ulcers and the difference between Gastric and Duodenal

Answer 3

Epigastric Pain (1-3 hours post prandial) 
Nausea
Bloating, Flatulence, Fatty meal intolerance 

DU 2-3x more common, location

Question 4

Investigations of PU

Answer 4

C13-Urea breath test
Stool antigen test
Serology
Endoscopy - biopsy