Inflammatory Bowel Disease Flashcards

1
Q

Describe the morphology and pathological consequences of Crohn’s disease and Ulcerative Colitis

A

Crohns - any part of GI tract, Oral & perianal, Discontinuous, Deep ulcers and fissures in mucosa (cobblestone) Transmural inflammation, Granulomas 50%

UC - Colon only, starts in rectum and continuously extends, red mucosa, easily bleeds, ulcers & pseudopolyps, mucosal inflammation

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2
Q

Common presenting symptoms

A

Crohns - Small bowel - Pain, Weight loss. Ileum - Acute abdomen (appendicitis) Colon - Diarrhoea, Bleeding and Pain on defecation

UC - Diarrhoea with blood and mucus

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3
Q

Extra-colonic manifestations of IBD

A

Mouth ulcers, Clubbing, Conjunctivitis, Arthritis, Malnutrition, Renal stones, Erythema nodosum, Ankylosis spondylitis, Chronic liver disease

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4
Q

Investigations

A

FBC (anaemia bleeding/iron/B12/folate, Platelet, ESR, CRP)

Sigmoidoscopy + biopsy, Colonoscopy, Small bowel imaging, US, Xray

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5
Q

Operative procedures used to treat IBD

A

Tend not to operate in Crohns due to high relapse rate

UC - Colectomy with ileoanal anastamosis

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