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GIT-PHARMA > Peptic Ulcer Disease > Flashcards

Peptic Ulcer Disease Flashcards

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Git Commands flashcards
1
Q

Triple therapy for H. pylori infection is composed of?

A

PPI (omeprazole) + clarithromycin + amoxicillin

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2
Q

Omeprazole is a proton pump inhibitor (PPI) that blocks gastric acid secretion by directly inhibiting _________

A

H/K ATPase

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3
Q

__________ is useful in NSAID induced ulcers

A

Misoprostol

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4
Q

Ranitidine and cimetidine are both ___________, useful in PUD

A

H2 antagonists

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5
Q

Side effect of cimetidine??

A

Gynecomastia

Galactorrhea

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6
Q

Which antibiotic is central to H pylori treatment?

A

Clarithromycin

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7
Q

NaHCO3 and CaCO3 are systemic antacids because

A

They get absorbed from the gut

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8
Q

Magnesium hydroxide and aluminum hydroxide are not absorbed from the bowel and don’t cause systemic side-effects such as __________

A

Alkalosis

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9
Q

_________ are used for immediate symptomatic relief of heartburn

A

Antacids

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10
Q

Which vitamin deficiency is associated with the use of PPIs?

A

B12

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11
Q

Antacids decrease absorption of oral __________ via chelation

A

Tetracyclines

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12
Q

A patient who regularly takes antacids for his heart burn develops pneumonia and is put on an antibiotic course for 5 days. The absorption of which of the following antibiotics would decrease due to his antacid use?

A

Tetracycline

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13
Q

________ are not recommended for treatment of active peptic ulcer

A

Antacids

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14
Q

____________ is a surface acting agent added with antacids to disperse the foam

A

Simethicone

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15
Q

__________ has no antacid or ulcer healing properties

A

Simethicone

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16
Q

Antacids increases the rate of elimination of _________ and ___________

A

phenobarbitone and salicylates

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17
Q

Antacids decreases the elimination of four drugs. Name them.

A

amphetamine
ephedrine
mecamylamine
quinidine

18
Q

What are the functions of misoprostol?

A

modest acid inhibition
stimulates mucus and bicarbonate ions secretion
enhances mucosal blood flow

19
Q

20% of patients have _________ (diarrhea/constipation) and cramping abdominal pain using misoprostol however, this is dose-dependent

A

Diarrhea

20
Q

All H2 receptor antagonist except __________ inhibit gastric first pass metabolism of ethanol and increase its bioavailibility

A

famotidine

21
Q

__________ cause hypergastrinemia that leads to carcinoid tumors in rats

A

PPIs

22
Q

__________ inhibit the cytochrome p450 metabolism of warfarin and phenytoin.

A

PPIs

23
Q

Antacids are weak bases that are taken _________

A

orally

24
Q

What are the functions of antacids?

A

partially neutralize gastric acid
reduce pepsin activity
stimulate prostaglandin production

25
Q

__________are still used commonly by patients as nonprescription remedies for dyspepsia

A

Antacids

26
Q

Why pepsin activity is reduced by using antacids?

A

pepsin is inactive at a gastric pH of greater than 4 and antacids increase the pHq

27
Q

________ antacids should not be used for long-term treatment

A

Sodium bicarbonate

28
Q

Sodium bicarbonate is contraindicated in three conditions?

A

HTN
Heart failure
Renal failure

29
Q

Why can’t we give sodium bicarbonate to hypertensive patient?

A

because its high sodium content can increase fluid retention

30
Q

What does sodium bicarbonate do in the body?

A

Produces transient metabolic alkalosis

Increases sodium load

31
Q

__________ antacid may stimulate gastrin release and thereby cause rebound acid production

A

Calcium carbonate

32
Q

Adverse effect of magnesium hydroxide?

A

diarrhea

33
Q

MgOH2 is a ________ (rapid/slow) acting antacid

A

rapid

34
Q

Aluminium hydroxide is a __________ (rapid/slow) acting antacid

A

slow

35
Q

Adverse effect of aluminium hydroxide?

A

Constipation

Encephalopathy

36
Q

Food _______ (shortens/prolongs) the duration of action of antacids.

A

prolongs

37
Q

Do not use antacids w/i 2hrs of administration of ?

A

Iron
Tetracyclines
Fluoroquinolones
Itraconazole

38
Q

__________ has a particular affinity for exposed proteins in the crater of duodenal ulcers

A

Sucralfate

39
Q

Whats in sucralfate?

A

Aluminium hydroxide

Sulfated sucrose

40
Q

Sucralfate produce _________ and nausea

A

constipation

41
Q

Sucralfate is used in critical care settings to prevent ___________ bleeding

A

stress-related

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