Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

GIT-PHARMA > Laxatives > Flashcards

Laxatives Flashcards

You may prefer our related Brainscape-certified flashcards:
Git Commands flashcards
1
Q

What are the bad things about laxatives?

A

Can cause electrolyte imbalance
Impaired drug absorption
Dependency

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Senna is a stimulant/irritant and its ised w/ docusate containing stool softener for the tx of _______ induced constipation.

A

Opioid induced

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Senna is given _______ (ROA) and causes evacuation in 6-12 hrs

A

Orally

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Bisacodyl
MOA?
ROA?

A 
MOA = stimulates nerve fibers in colon mucosa
ROA = suppository & enteric coated tablets
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Castor oil shouldn’t be used in pregnant women because?

A

It may cause uterine contractions

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Why is castor oil not recommended?

A

Poor palatability

GI adverse effects

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What is the mechanism of action of bulk laxatives?

A

Form gells in the intestine that attract water (cause water retention)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

When are bulk laxatives not used?

A

In immobile patients (risk of intestinal obstruction)

In people with gut ulceration

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

When are bulk laxatives used?

A

For tx of chronic constipation

Irritable bowel syndrome

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What are some conditions when taking bulk laxatives?

A

Generous water intake
Straining at stool has to be avoided
If taking any drugs, 2 hour gap is need

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What are the names of bulk laxatives?

A

Psyllium
Methyl cellulose
Bran
Seed

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What are the adverse effects of bulk laxatives?

A

Bloating

Flatulence

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What are the adverse effects of stimulants?

A

If used chronically, cathartic colon develops (colonic distention)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What are the types of osmotic laxatives?

A

Salt free

Salt containing

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What is the advantage of salt free osmotic laxatives?

A

Less cramping and gas (PEG powder w/o electrolytes)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What are the salt containing osmotic laxatives? And MOA?

A

Mg hydroxide
Mg citrate
MOA = Hold water in intestine by osmosis

17
Q

What are the uses of polyethylene glycol?

A

To prepare the bowel for colonic lavage

18
Q

What is the MOA of lactulose?

A

Lactulose goes in colon undigested and there the bacteria ferment them into lactic, formic and acetic acid and increasing osmotic pressure

19
Q

For what other reason lactulose is used?

A

Hepatic encephalopathy (because it can reduce ammonia levels)

20
Q

Stool softener or emollient laxatives are used for _________ (treating/prophylaxis of) constipation

A

Prophylaxis (because it may take days to become effective)

21
Q

Stool softener like docusate should not be used w/ __________ bcz of potential for absorption

A

Mineral oil

22
Q

Laxatives are stool softener also called __________ (aperients/cathartics)

A

Aperients

23
Q

Purgatives increase peristaltic activity and are also called ________ (aperients/cathartics)

A

Cathartics

24
Q

What is the moa of stool softeners?

A

It emulsifies w/ the stool produce softer stools

25
Q

What are some lubricant laxatives?

A

Mineral oil

Glycerin suppositories

26
Q

Mineral oil should be taken orally in _______ (position) to avoid it aspiration and potential for lipids or lipoid pneumonia

A

Sitting upright

27
Q

What is the adverse effect of mineral oil?

A

Leakage of oil can cause irritation of the anus

28
Q

Lubiprostone is a chloride channel activator and it’s used for the tx of?

A

Chronic constipation

Irritable bowel syndrome constipation

29
Q

How does lubiprostone work?

A

Activate chloride channels in the intestine and increase fluid secretion

30
Q

What are the advantages of lubiprostone

A

No drug dependency
Minimal drud drug interactions
Little change in electrolyte imbalance

31
Q

Why are the drug drug interaction minimal for lubiprostone

A

Its metabolism occurs quickly in stomach and jejunum

32
Q

Lubiprostone is indicated in ______ w/ IBS-C

A

Women

33
Q

Adverse effects of lubiprostone

A

N/V/dyspepsia
Headache
Dizziness/ hypotenstion

GIT-PHARMA (4 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions