Pentose Phosphate Pathway (complete) Flashcards
In what cells does the pentose phosphate pathway occur
all cells
where in all cells does the pentose phosphate pathway occur
the cytoplasm
What are the two branches of the pentose phosphate pathway
- Oxidative Branch
2. Non Oxidative Branch
What is the purpose of the pentose phosphate pathway
- Production of NADPH
2. Production of Ribose-5-phosphate
What does NADPH do
- used in fatty acid synthesis
- used in steroid synthesis
- transformation of xenobiotics
- reduction of oxidized glutathione
What does Ribose-5-Phosphate do
Nucleotide synthesis (provides the sugar and phosphate portions of a nucleotide)
From which intermediate in glycolysis does the oxidative branch of the pentose phosphate pathway branch off
Glucose-6-phosphate
What is the initial enzyme used in the oxidative branch of the pentose phosphate pathway
Glucose-6-P dehydrogenase
How Many NADPH are formed in the oxidative branch of the pentose phosphate pathway
2
How many Ribose 5 phosphate are formed from the oxidative branch of the pentose phosphate pathway
1
What regulates the activity of Glucose-6-Phosphate dehydrogenase (G6PDH)
NADPH
High levels of NADPH inactivate G6PDH
Of the four reactions in the oxidative branch of the pentose phosphate pathway how many are irreversable
3 of the 4 are irreversable (first 3)
Does NADPH mostly exist as NADPH or NADP+
NADPH
NADPH:NADP+ (100:1)
Does NADH mostly exist as NADH or NAD+
NAD+
NADH:NAD+ (1;100)
What vitamins are necessary for the synthesis of NADPH
Niacin and Vitamin B3
In our lecture what was the most emphasized role of NADPH
the reduction of oxidized glutathione