Pentose Phosphate Pathway

Question 1

What’s a defiecny of the pentose phosphate pathway?

Answer 1

Glucose-6-phosphate dehydrogenase
-rate limiting step

Causes hemolytic anemia, low levels of NADPH leads to low levels of reduced glutathione in RBC (sickle cell anemia)

Question 2

What is Mode 1 of the PPPathway?

Answer 2

Cell/body has more ends for ribose 5-phosphate than for NADPH

Why is NADPH not made in this pathway??

Because the decarboxylation/oxidative step is skipped. Makes a ribose instead of RIBULOSE

Question 3

What do you get from mode 2 of the pentose phosphate pathway?

Answer 3

Cell has need for NADPH and ribose 5-phosphate

The oxidative step gives the NADPH but also a ribulose so more steps are needed. Balanced need

Question 4

What’s expected to come out of mode 3?

Answer 4

Cells needs more NADPH than ribose 5-phosphate,

The ribolose gets recycled by
Going through a fructose/glucose form G6P and make more NADPH

Question 5

What cellular circumstances would push the pentose phosphate pathway to mode 4?

Answer 5

Needs for NADPH and ATP

The ribulose/ribose enters glycolysis and goes through the cycle to give pyruvate.

Question 6

What’s an important factor/function of G6PD that is good for longevity?
(Not NADPH production)

Answer 6

G6PD is an antioxidant, it deals with reactive oxygens species in the body.