Penicillins Flashcards
What are the 4 types of Penicillins
- Penicillinase-resistant Pencillins
- Antipseudomal Penicillins
- Narrow Spectrum Penicillins
- Broad Spectrum Penicillins
Examples of Penicillinase-resistant Pencillins
Flucloxacillin
Examples Antipseudomal Penicillins
- Piperacillin
- Ticarcillin
(both only available in combination)
Examples Narrow Spectrum Penicillins
- Penicillin G (Benzylpenicillin)
- Penicillin V (phenoxymethylpenicillin)
Examples Broad Spectrum Penicillins
- Amoxicillin
- Ampicillin
When to take flucloxacillin
empty stomach (1 hour before, or 2 hours after food)
Side effects of Flucloxacillin
- Cholestatic Jaundice
(can occur up to 2 months after treatment) - Hepatitis
Risk factors of Flucloxacillin induced Hepatitis
- more than 2 week treatment
- age
What are the routes of administration for the Narrow Spectrum Penicillins
- Penicillin G (Benzylpenicillin)
Parental only - Penicillin V (phenoxymethylpenicillin)
oral
Which Pencillins are Beta Lactamase Sensitive
- Narrow Spectrum
- Broad spectrum
Which Pencillins are Beta Lactamase Resistant
Co-Amoxiclav
(Amoxicillin + Clavulanic Acid)
What can Penicillin induced Diarrhoea lead to
Antibiotic Associated Colitis
(broader the antibiotic, larger the side effects)
Why should you not use Broad Spectrum blindly for sore throat
Amoxicillin + Glandular Fever =
Maculopapular rashes
What microbe causes glandular fever
Epstein-Barr virus
What complication can come out of giving Penicillins intrathecally (spine)
Encephalopathy (fatal)
