Aminoglycosides

Question 1

Examples of Aminoglycosides

Answer 1

• Gentamycin
• Neomycin

Question 2

Which patients should you monitor Aminoglycosides serum levels when giving them IV Aminoglycosides

Answer 2

• Obese
• At high doses
• Cystic Fibrosis
• Elderly

Question 3

Aminoglycosides monitoring times

Answer 3

After 3 to 4 doses
==> every 3 days
====> after a dose change

Question 4

When to measure Aminoglycosides serum levels when it is time to measure them

Answer 4

PEAK and TROUGH levels
- 1 hour after dose
- 1 hour before next dose

Question 5

What should PEAK serum concentrations of Aminoglycosides be

Answer 5

5 to 10 mg/L

Question 6

What should TROUGH serum concentrations of Aminoglycosides be

Answer 6

<2mg/L

Question 7

When is Endocarditis serum levels for PEAK and TROUGH

Answer 7

PEAK:
3-5mh/L

TROUGH:
<1mg/L

Question 8

How to adjust dose if TROUGH level is too high

Answer 8

increase dose interaval

Question 9

How to adjust dose if PEAK level is too high

Answer 9

reduce dose strength

Question 10

How to adjust dose if mild to moderate renal impairment

Answer 10

increase dose interaval

Question 11

How to adjust dose if severe renal impairment

Answer 11

reduce dose strength

Question 12

What drugs to AVOID when taking Aminoglycosides

Answer 12

• Nephrotoxic drugs
• Ototoxic drugs

Question 13

What drugs cause Ototoxicity

Answer 13

• Cisplatin
• Loop Diuretics
• Vancomycin
• Vinca Alkaloids

Question 14

Aminoglycosides contraindications

Answer 14

• Myasthenia Gravis (abnormal muscle weakness)
• Pregnancy

Question 15

Why should you avoid Aminoglycosides in pregnancy

Answer 15

risk of vestibular nerve damage
(inner ear to brain nerve)

Question 16

How should we calculate dose for Obese patients

Answer 16

Ideal body weight