Penicillins Flashcards
Natural Penicillins
Include various penicillin G preparations and penicillin V potassium.
Natural Penicillin uses
(1) Gram-positive organisms (streptococci, Enterococcus
faecalis, and Listeria monocytogenes). (2) anaerobic species (Bacteroides and Fusobacterium). (3) By parenteral can be used to treat some gram-negative bacteria (E coli, H. influenzae, Neisseria gonorrhoeae, & Treponema pallidum)
The Aminopenicillins
ampicillin and amoxicillin
The Aminopenicillins uses
gram-positive organisms, plus improved coverage of selected gram-negative bacilli, (Enterobacteriaceae). Uses: sinusitis/bronchitis, susceptible urinary tract infection
Amoxicillin
500mg q 8h or 875 q 12h for 5-7 days (UTI)
Amoxicillin-clavulanate
500-875 q 8-12 hours for 5-7 days (UTI)
The Penicillinase-Resistant Penicillins
Nafcillin and oxacillin, which are parenteral formulations. Dicloxacillin, which is given orally
Dicloxacillin
500mg q 6 hours for 10-14 days (Mastitis)
The Penicillinase-Resistant Penicillins uses
useful against
penicillin-resistant (methicillin-sensitive) Staphylococcus species
The Antipseudomonal Penicillins
ticarcillin and piperacillin
The Antipseudomonal Penicillins use
gram-positive bacteria, but they also have more activity against gram-negative bacteria, including Pseudomonas aeruginosa. Additional gram-negative species that are treated by these agents include H.
influenzae, Serratia species, and Klebsiella species