Pemphigoid variants

Question 1

Pemphigoid vegetans presents as:

Answer 1

• vegetative plaques in intertrigenous areas

Question 2

Pemphigoid nodularis resembles _____, and typically lacks ______

Answer 2

• resembles prurigo nodularis
• lacks bullae

Question 3

Lichen planus pemphigoides is overlap between which to diseases?

Answer 3

LP and bullous pemphigoid

Question 4

clinical presentation of lichen planus pemphigoides:

Answer 4

• LP-like palpules and plaques and tense bullae arising in skin unaffected by LP

Question 5

pemphigoid gestationis presents in which trimester?

Answer 5

• Any trimester (second and third most commonly) or immediately post-partum

Question 6

pemphigoid gestationis is a/w:

Answer 6

• trophoblastic tumors (choriocarcinoma, hydatiform mole)
• premature delivery

- Graves disease

Question 7

What part of body does pemphigoid gestationis typically first appear?

Answer 7

• umbilicus

Question 8

Genetic associations of pemphigoid gestationis:

Answer 8

• HLA-DR3 or HLA-DR4

Question 9

DIF findings of pemphigoid gestationis:

Answer 9

• linear C3 (100%) > linear IgG (30%)

Question 10

Best serum test for pemphigoid gestationis:

Answer 10

• ELISA for BP180-NC16A (same for BP)

Question 12

Treatment of pemphigoid gestationis:

Answer 12

• systemic steroids

Question 13

Most common causes of drug induced pemphigoid:

Answer 13

• Fat Abdomen Covered By Pemphigoid
• Furosemide

-ACE-I

- cephalosporins

- B-lactams

- D-Penicillamine

Question 14

Pemphigoid variant often a/w psoriasis is called____ and the target antigen is _____

Answer 14

• Anti-p200 pemphigoid
• Laminin lambda-1