Bullous systemic lupus erythematosus

Question 1

Bullous SLE pathogenesis?

Answer 1

• IgG autoantibodies against collage VII

Question 2

Bullous SLE presentation?

Answer 2

Vesicles/bullae arising on urticarial background

Question 3

Histopathology of Bullous SLE:

Answer 3

neutrophil predominant subepidermal blister

Question 4

DIF of Bullous SLE:

Answer 4

continuous granular pattern along BMZ (multiple immunoreactants including IgG, C3, IgA, IgM)

Question 5

Salt split skin DIF of Bullous SLE:

Answer 5

• dermal staining

Question 6

Treatment of bullous SLE?

Answer 6

DAPSONE

Question 7

What 3 autimmune blistering disorders have Abs against Collagen type 7?

Answer 7

1. EBA

2. COL 7a form of LABD

3. Bullous SLE