Pelvic Pain Flashcards

1
Q

What is chronic pelvic pain?

A

-Intermittent or constant pain in the lower abdomen or pelvis of a woman of at least 6 months induration, not occurring exclusively with menstruation or intercourse and not associated with pregnancy

1 in 4 women

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2
Q

Causes of chronic pelvic pain

A

-Gynaecological : Endometriosis, adhesions, adenomyosis, leiomyoma, pelvic congestion syndrome, ovarian cysts, pelvic inflammatory disease, malignancy
-Gastrointestinal : Adhesions, appendicitis, constipation, diverticular disease, irritable bowel syndrome, inflammatory bowel disease
-Urinary tract : Urinary tract infection, calculus, interstitial cystitis, bladder pain syndrome
-Skeletal : Degenerative joint disease, scoliosis, spondylolisthesis, osteitis pubis
-Myofascial : Fascitis, nerve entrapment syndrome, hernia
-Psychological : Somatization, psychosexual dysfunction, depression
-Neuropathic : Pudendal nerve entrapment, spinal cord neuropathies, fibromyalgia

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3
Q

History of chronic pelvic pain

A

-Pain history
=Dysmenorrhea
=Dysparunia (Superficial at entrance to vagina/ deep)
=Non cyclical pain (pelvic congestion syndrome= when standing for long time/ change in bowel function adhesions/ cysts sore always)
=Neuropathic features
=Cycle, HMB/IMB
=Bowel/bladder (on defecation and bladder distention)
-Fertility
-Fatigue/QoL (working, relationships)
-Abuse
-Past O&G
-PMH/DH/SH/FH
-Previous Ix
-Previous Rx

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4
Q

Examination of pelvic pain

A

-Inspection
-Abdominal palpation: inspection for distention or masses, tenderness, rebound and guarding, auscultation if obstruction or ileus
-Speculum (abnormal discharge or bleeding) and bimanual (uterine or adnexal enlargement if pelvic mass, fibroids, ovarian cyst, cervical excitation in ectopic pregnancy and pelvic infection)
=A fixed, immobile uterus suggests multiple adhesions, and nodules felt on the uterosacral ligaments can be a feature of endometriosis
-(Neuropathic pain features/pelvic
floor/MSK.

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5
Q

Epidemiology of endometriosis

A

-1 in 10 women
=Line peritoneum on laparoscopy

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6
Q

Cause of endometriosis

A

-Implantation theory: retrograde menstruation (tissue implants in peritoneum as endometrium refluxes into pelvis)
-Coelomic metaplasia theory: Mullerian duct/ peritoneal and pleural cavities/ ovaries
-Natural history?

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7
Q

Three subtypes of endometriosis

A

-Peritoneal superficial lesions (80%): little lesions, cannot see on scan
-Deep infiltrating lesions (5mm invasion, more fibrotic, back of uterus or pelvic side walls- rectal symptoms/ uretic obstruction)
-Ovarian endometrioma cysts (chocolate cysts)

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8
Q

Symptoms of endometriosis

A

-Fatigue/ lack of energy
-Severe period pain
-Heavy menstruation
-Pelvic pain
-Pain on defecation
-Depression/ isolation
-Infertility
-Painful urination
-Constipation and/or diarrhoea
-Painful intercourse

-Increased risk of ovarian and breast cancer, melanoma, asthma, and some autoimmune, cardiovascular, and atopic diseases

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9
Q

Why does endometriosis cause pain?

A

-Endometrial like cells respond to circulating hormones
-Inflammatory= recruitment of cells, macrophages, cytokines
=Stimulate peripheral nerve fibres

-Hypoxia in lesions after withdrawal of progesterone

-Stretch in ovarian cortex in cysts

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10
Q

When to suspect endometriosis

A

-Including young women aged 17 and under, with 1 or more:

=Chronic pelvic pain
=Period-related pain (dysmenorrhoea) affecting daily activities and QOL
=Deep pain during or after sexual intercourse
=Period-related or cyclical GI symptoms, in particular, painful bowel movement
=Period-related or cyclical urinary symptoms, in particular, blood in the urine or pain passing urine
=Infertility in association

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11
Q

What needs to be assessed/ discussed in suspected endometriosis?

A

-Circumstances, symptoms, priorities, desire for fertility, aspects of daily living, work and study, cultural background, and their physical, psychosexual and emotional needs
-Discuss keeping a pain and symptom diary
-Offer an abdominal and pelvic examination to identify abdominal masses and pelvic signs
-Consider ultrasound scan

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12
Q

Investigations of endometriosis

A

-Swabs if indicated
-MSU
-USS
=Endometrioma
=Sliding sign (adhesions)
=Deep disease
=Adenomyosis
=Other pathology
-Specialist assessment:
=MRI (deep, surgical planning)
=Cystoscopy (does it affect bladder)
=Sigmoidoscopy

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13
Q

Types of ultrasound in endometriosis

A

-Consider transvaginal ultrasound:
=to investigate suspected endometriosis even if pelvic and/or abdominal examinations are normal
=for endometriomas and deep endometriosis involving the bowel, bladder or ureter.
-Consider a transabdominal ultrasound scan of the pelvis if a TVS is not appropriate

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14
Q

Biomarkers of endometriosis

A

-Ca-125 not diagnose endometriosis
-Nothing has worked

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15
Q

Diagnosis of endometriosis

A

-Consider laparoscopy to diagnose endometriosis, even if the ultrasound was normal (gun powder lesions/ peritoneal pockets, different colours)
-During diagnostic laparoscopy, a gynaecologist with training and skills in laparoscopic surgery for endometriosis should perform a systematic inspection of the pelvis
=Sigmoid rectal
=Appendix
-If a full systematic laparoscopy is performed and is normal, explain to the woman that she does not have endometriosis and offer alternative management

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16
Q

Aims of management of endometriosis

A

-Symptoms
-Previous treatment
-Contraception requirement
-Fertility intent
-Disease phenotype

17
Q

Overall endometriosis management

A

-Expectant (asympotmatic)
-Pain management
=Analgesia
=Neuromodulator
=Physiotherapy
=Psychology
=Self management
-Disease specific
=Hormonal (suppression as oestrogen dependent)
=Surgery

18
Q

Hormone suppressive therapies in endometriosis

A

-All approaches equally effective, symptoms recur when stopped, side effects, contraceptive

-Combined (oral, patch, ring)= nausea and headache
-Progestogens (oral, IM, SC, IUS)= weight gain, bloating, acne, unscheduled bleeding
-GnRH agonists (intranasal, IM, SC)= vaginal dryness, vasomotor, BMD
-GnRH antagonists (oral)= vaginal dryness, vasomotor, BMD
-Aromatase inhibitors (oral)= vaginal dryness, vasomotor, BMD

19
Q

Surgery to improve pain in endometriosis

A

-Burn/ cut/ laser
-Subtype dependent
=Deep: 70% long-term improvement but high complication risk
=Endometriomas: strip out capsule, reduce ovarian reserve
=Peritoneal: less use, high risk of recurrence

20
Q

Complementary treatments in endometriosis

A

-Vitamin
-Acupuncture
-Cannabis
-Chinese medicine/ turmeric/ dietary modification

21
Q

Causes of endometriosis-associated subfertility

A

-Oocytes are of poor quality?
-Oocytes are not released from the ovaries each month (anovulation)?
-Pelvic adhesions inhibit the movement of the oocyte down the Fallopian tube?
-Chemicals produced by the endometriosis inhibit the movement of the oocyte down the Fallopian tube and impact on embryo implantation?
-Inflammation in the pelvis caused by endometriosis stimulates the production of cells that attack the sperm and shorten their life span?
-Impact of dysparunia

22
Q

Wanting conception in endometriosis

A

-Subfertility?
=Tubal assessment
=EFREC referral

-Conservative
=Analgesia
=Neuropathic pain management (TCA better safety profile than SNRI/gabapentin)
=GnRH if already waiting for IVF

-Surgical
=SPE: benefit of surgery for spontaneous conception
=Endometrioma: mixed evidence (Loss of reserve/ IVF: access/infection vs loss of reserve)
=Stripping vs Drain with downstream definitive surgery
=Deep: no benefit for pregnancy outcomes, pain management vs delay in IVF

-Pregnancy: increased risk of miscarriage, ectopic, preavia, APH, PTB and PPH

23
Q

Causes of refractory chronic pelvic pain

A
  1. Endometriosis
  2. Adhesions
  3. Neuropathic
  4. Musculoskeletal
  5. Non gynae pathology: IBS, PBS
  6. Psychological
  7. Cancer

-40-55% will have no pathology seen at laparoscopy

24
Q

What occurs at a combined chronic pelvic pain clinic?

A

-Nurse specialist
-Psychologist
-Pain physician
-Gynaecologist
-Physiotherapist

25
Q

Management of refractory chronic pelvic pain

A

-Further investigation
=Endometrial biopsy
=Pelvic USS
=Laparoscopy

-Appropriate treatments
=Ovulation suppression
=Antispasmodics
=Analgesia (NSAIDs, neuromodulators like amitriptyline, gabapentin, lidocaine)
=Role of surgery (adenomyosis)
=Diet (more likely to IBS x3 as cross sensitisation))
=Physio
=Pelvic pain management program
=CBT/ mindfulness
-Rescue plan for flares

26
Q

Causes of acute pelvic pain

A

-Gynaecological : Ectopic pregnancy, miscarriage, acute pelvic infection, ovarian cysts (torsion, rupture)
-Gastrointestinal : Appendicitis, constipation, diverticular disease, irritable bowel syndrome, inflammatory bowel disease
-Urinary tract : Urinary tract infection, renal stones
-Other causes : Musculoskeletal

27
Q

Investigation in acute pelvic pain

A

-If the UPT is negative, a high vaginal swab, endocervical swab and full blood count should be performed to investigate for infection.
-All sexually active women below the age of 25 years who are being examined can be offered opportunistic screening for Chlamydia .
-An ultrasound scan is helpful in identifying ovarian cysts.