Peds Rheum/Ortho Flashcards
4 criteria of Juvenile idiopathic arthritis (JIA)
1) onset 6mon - 16yo
2) arthritis 1+ joints (edema, warmth, inflam, tender, limited ROM) x 6 wks
3) sx’s present 6 months
4) Can’t be explained by vasculitis, neoplasm, infection, CT disorder
Most common JIA
Oligo JIA
What should be monitored in children with JIA?
eyes; slit lamp exam q 6 months for increased risk of iritis and uveitis
Difference between oligo and polyarticular JIA
oligo 1-4 joints and poly 5+
RF always neg in oligo but can be pos or neg in poly
5 yo with asymmetric arthritis for 6 months plus plaques on extensor surfaces and nail pitting
psoriatic JIA
young child with limp and found to have swollen knee joint which is warm and tender. Positive ANA
Oligo JIA
Rheumatic condition in children with +HLA B-27
enthesitis JIA
How are JIAs treated?
1st line: NSAIDs
Methotrexate
Steroids (intra-articular or systemic)
DMARDs (rheumatic sx’s)
+ skin PE of psoriasis rash
Auspitz sign = bleeding when scale removed
Koebner phenomena = increased rxtn at site of trauma
Juvenile arthritis + salmon colored rash associated with fever spikes
systemic onset JIA
Diagnostic criteria of fevers for systemic onset JIA
- fever spikes once per day for at least 2 weeks
- fevers accompanied by salmon colored rash which fades as fever goes away
- no signs of infection
JIA that doesn’t fit any category criteria called ______.
undifferentiated
Systemic Lupus Erythematosis (SLE) diagnostic criteria
4/11 criteria; mneumonic “SOAP Brain MD”
Serositis
Oral Ulcers (painless)
Arthritis/Arthralgia
Photosensitivity
Blood (Hematologic) Disorder Renal Abnormality ANA Immunologic Disorder (Serologies) Neurologic Disorders
Malar Rash ("butterfly") Discoid Rash ("coin")
How is SLE ruled out?
(-) ANA
SLE treatment
Symptomatic: sunscreen, avoid cold, NSAIDs, anti-HTN, aspirin (for thrombosis)
Disease-specific: steroids, Belimumab, hydroxychloroquine
How is neonatal lupus acquired?
maternal antibodies (anti-Ro and anti-La) to neonate
Common manifestations of NLE
rash, cytopenias, hepatomegaly
Earliest sign of heart block in due to NLE? How is this treated?
fetal tachycardia
give steroids antenatal ASAP; pacemaker in infancy
Drugs that induce lupus
seizure meds (phenytoin, carbamazepine)
psych meds
isoniazid
minocycline
Dx of drug-induced lupus
+ anti-histone antibodies
+ ANCA