peds deck 7 Flashcards
pharmacokinetic considerations of midazolam
- crosses BBB 2. absorbed in the GI 3. metabolized by CYP450
midazolam acts on what receptors
its a GABA agonist
what pediatric populations would you consider giving midazolam
- preop for separation anxiety
T/F: it is common to give midazolam to neonates
FALSE
what receptors do propofol work on
NMDA and GABA (but primarily GABA)
dose of propofol in peds for induction
2-5 mg/kg
infusion rate of propofol
100-300 mcg/kg/min
s/e of propofol
- decreases CMRO2, CBF, and ICP 2. decrease SBP 3. HR - unchanged or inc or dec 4. dose dep respiratory depression
why do we like propofol in peds
- quick on and off 2. easily accessible 3. low s/e profile 4. antiemetic and anticonvulsant properties
what pediatric pts in propofol c/i in?
- mitochondrial d/o 2. central hyopventilation d/o
MAC of isoflurane in children
1.2
MAC of sevoflurane in children
2.2
MAC of desflurane in children
6.8
neurologic s/e of INH anesthetics
- decreased CMRO2 2. increased CBF 3. increased ICP
CV s/e of INH anesthetics
- dose dep dec in BP 2. HR - desflurane will increase; sevoflurane can decrease
respiratory effects of INH anesthetics
- increases RR 2. Tv decrease 3. DD decrease in airway resistance
what is the most commonly used inhalational agent in peds
sevoflurane
T/F: there is no advantage to one INH agent over another in regards to inducing neuroapoptosis
TRUE
_____________ does not cause neuroapoptosis, but does when it is used in conjunction with other volatiles
N2O
the highest degree of neurapoptosis was found when INH agents were used with _____________, ___________, or _____________
ketamine; midazolam; N2O