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HEMA 1 Finals > Pedriatric & Adult Hematopoiesis > Flashcards

Pedriatric & Adult Hematopoiesis Flashcards

1
Q

Percentage of Bone marrow in newborn and bone marrow is

A

80-90%
Active bone marrow

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2
Q

Percentage of Bone marrow in young adult (Age 20) and bone marrow is

A

60%
Active
(Hematopoiesis: proximal ends of large flat bones, pelvis, sternum or in long bones)

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3
Q

Percentage of Bone marrow in old adult (Age 55) and bone marrow is___ the other percentage is ___

A

40%
Active
Fat

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4
Q

What is Cellularity?

A

It is the ratio of marrow cells to fat (red marrow/yellow marrow)

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5
Q

Examples of Cellularity

A
  1. Normocellular
  2. Hypercellular/ Hyperplastic
  3. Hypocellular/ Hypoplastic
  4. Aplastic
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6
Q
  • Normocellular: marrow has ____
  • Hypercellular/ Hyperplastic: marrow has ____
  • Hypocellular/ Hypoplastic: marrow has ____
  • Aplastic: marrow has ____
A
  • 30-70% hematopoietic cells
  • > 70% hematopoietic cells
  • <30% hematopoietic cells
  • few or no hematopoietic cells
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7
Q

It is the ratio of GRANULOCYTES and their PRECURSORS to NUCLEATED ERYTHROID PRECURSORS

A

M:E (Myeloid: Erythroid) Ratio

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8
Q

Normal ratio of M:E (Myeloid: Erythroid) Ratio

A

3:1 or 4:1

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9
Q

These are excluded from M:E ratio

A

Lymphocytes
Monocytes

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10
Q

Types of Hematopoiesis

A
  1. Pluripotential stem cells
  2. Committed progenitor cells (Lymphoid/ Myeloid)
  3. Mature Blood Cells (PBS is used for assessment)
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11
Q

Additional types of Hematopoiesis

A

1.Diff. Ct. Smear
2. PBS

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12
Q

Simply counting the number of types of WBC

A

Diff. Ct. Smear

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13
Q

Special request to identify RBC morphology, especially & blast cells

A

PBS

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14
Q

Committed progenitor cells

A
  • CGU-MEG
  • CFU-GM (CFU-M)
  • CFU-GM (CFU-G)
  • BFU-E (CFU-E)
  • CFU-Eo
  • CFU-Bs
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15
Q

CGU-MEG
Growth factors/ Interleukins: _____
Mature Cells: _____

A

Thrombopoeitin, GM-CSF
Thrombocytes

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16
Q

CFU-GM (CFU-M)
Growth factors/ Interleukins: _____
Mature Cells: _____

A

GM-CSF, M-CSF, IL-3
Monocytes

17
Q

CFU-GM (CFU-G)
Growth factors/ Interleukins: _____
Mature Cells: _____

A

GM-CSF, G-CSF, IL-3
Neutrophils

18
Q

BFU-E (CFU-E)
Growth factors/ Interleukins: _____
Mature Cells: _____

A

Erythropoietin, GM-CSF, IL-3
Erythrocytes/ RBC

19
Q

CFU-Eo
Growth factors/ Interleukins: _____
Mature Cells: _____

A

GM-CSF, IL-3, IL-5
Eosinophils

20
Q

CFU-Bs
Growth factors/ Interleukins: _____
Mature Cells: _____

A

IL-3, IL-4
Basophils

21
Q

Erythrocytes/ RBC Components

A

Globin
Other components (cell membrane, iron)

22
Q

Contains both alpha and beta polypeptide chain

A

Globin

23
Q

semi-permeable so electrolytes can pass through

A

Cell membrane

24
Q

It is where O2 binds

A

Iron

HEMA 1 Finals (4 decks)

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