Introduction To RBC disorders

Question 1

Process of blood production

Answer 1

Hematopoiesis

Question 2

building up of blood components– RBC, WBC, and platelets

Answer 2

Hematopoiesis

Question 3

Phases of Intrauterine Hematopoiesis

Answer 3

1. Mesoblastic Phase
2. Hepatic Phase
3. Myeloid/ Medullary Phase

Question 4

Site of Mesoblastic Phase

Answer 4

Yolk sac

Question 5

Mesoblastic phase begins at ____

Answer 5

19th day of gestation

Question 6

Mesoblastic phase is ______

Answer 6

Primitive Nucleated Erythroblast (first cell and doesn’t disappear even until adulthood)

Question 7

Embryonic Hgb in Mesoblastic phase

Answer 7

1. Gower l
2. Gower II
3. Portland

Question 8

Site of Hepatic Phase

Answer 8

Liver

Question 9

Hepatic Phase begins at ____

Answer 9

6 weeks of gestation

Question 10

Hepatic phase is production of ____

Answer 10

red blood cells, granulocytes, monocytes, and megakaryocytes

Question 11

Hepatic phase is _____

Answer 11

Alpha and gamma globin chain production (HbF)

Question 12

Site of Myeloid/ Medullary phase

Answer 12

Red bone marrow

Question 13

Myeloid/ Medullary Phase begins around _____

Answer 13

5th month of gestation

Question 14

Myeloid/ Medullary Phase
Is a bone marrow producing mainly ____

Answer 14

Granulocytes

Question 15

M:E (Myeloid:Erythroid) ratio

Answer 15

3:1 or 4:1

Question 16

In the Myeloid/ Medullary Phase gamma-beta globin chain switch at

Answer 16

6th months of age