Pedigree (younger)

Question 1

How many alleles are required for the disease to be expressed with autosomal recessive?

Answer 1

2 mutant alleles

Question 2

True/False: an affected person is usually born to unaffected parents.

Answer 2

True

Question 3

True/False: Only mother is obligate carrier with autosomal recessive.

Answer 3

False, both parents of the child are obligate carriers

Question 4

True/False: Male to male transmission can occur with autosomal recessive.

Answer 4

True

Question 5

True/False: With autosomal recessive it usually involves catalytic proteins.

Answer 5

True

Question 6

True/False: For x-linked there is male to male transmission of the mutant allele.

Answer 6

False, there is no male-male transmission

Usually only affects males.

Question 7

______________ is very rare, no high yield diseases.

Answer 7

x-linked dominant inheritance

Question 8

X-linked always means X-linked __________.

Answer 8

recessive

Question 9

What are some x-linked conditions?

Answer 9

Duchenne and Becker muscular dystrophy
Lesch-Nyhan (HGPRT deficiency purine recycling deficiency)
Glucose-6-phosphate dehydrogenase deficiency
Hemophilia A and B

Question 10

What are the only organelles in humans that contain their own DNA?

Answer 10

Mitochondria

Question 11

If you are talking about mitochondrial inheritance we know that we inherited the disease exclusively from what parent? Why?

Answer 11

Mother

During fertilization, sperm do not pass their mitochondria to the egg cell

Question 12

What are some facts of mitochondrial inheritance?

Answer 12

Only inherited maternally
Both males and females can be affected
All offspring of an affected female are affected
No offspring of an affected male are affected

Question 13

What is a disease example with mitochondrial inheritance?

Answer 13

LHON (leber Hereditary Optic Neuropathy)