Pediatric WBC newman

Question 1

how do you calculate ANC

Answer 1

(% bands + % neutrophils) X WBC (100)

Question 2

severe congenital neutrophnia have increased risk for what

what is the clnical manifestation

Answer 2

AML

life threat pyogenic infections, often in infancy

Question 3

cyclic neutropenia clinical manifestations

-inheritance

Answer 3

cyclic fever, oral ulcers, gingivitis, periodonal disease, recurrent bacterial infections

sporadic or AD

severe neutropenia under 200

Question 4

shwachman-diamond syndrome clinical manifestations and risk of malignancy

Answer 4

neutropenia, exocrine pancreas insufficiency, skeletal abnormaltiies

incresaed risk for MDS or leukemia

Question 5

fanconi anemia abnormalities

Answer 5

bone marrow failure syndrome
GU and skeletal abnormalities
toxic encephalopathy

Question 6

leukocyte adhesion deficiency clinical

-inheritance

Answer 6

delayed separation of umbilical cord over 3 weeks with recurrent and severe bacterial and fungal infections without pus accumulation
AR

Question 7

chronic granulomatous disease
clinical 
defect 
inheritance 
prognosis

Answer 7

recurrent pululent infections with fungal or bacterial catalase potitive organisms in infacny

defect in generation of superoxide

x linked recessive
good prognosis

Question 8

infection associated neutropenia from what virus

Answer 8

parvovirus B19

Question 9

drug induced neutropneia what drugs

Answer 9

cytotoxic agents for treatment of malignancies

Question 10

leukocytosis. if wBC is over what suspect marrow infiltration

Answer 10

> 100K.uL