platelet disorders Flashcards

1
Q

1/3 of pts with IDA have what

A

thrombocytosis

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2
Q

most common cause of bleeding is what

A

thrombocytopenia

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3
Q

patients with ET may have what symptoms

A

bleeding, thrombosis or both

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4
Q

petechiae are common in what

what else

A

thrombocytopenia

purpura

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5
Q

what is Erythromelalgia and when can it occur

treat with what

A

pts with ET
burning pain and redness in hands
respond to baby ASA daily

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6
Q

what is pseudothrombocytopenia

A

can be seen in CBC drawn in EDTA tube
in vitro clumping
repeat CBC in heparin or citrate tube

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7
Q

what drugs can lower the platelet count

A

H2 blockers
antibiotics
loop diuretics
digoxin

HALD the plate

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8
Q

what antibiotics most commonly cause thrombocytopenia

A

cephalosporins and amino penicillins

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9
Q

what increases risk of ITP

A

h pylori
CT disease
CLL
lymphomas

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10
Q

what would the platelet count be in ITP

A

probably below 30 k

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11
Q

dont have to treat ITP with a platelet count over what

A

35,000

especially if only has petichiae and no other symptoms

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12
Q

what is treatment in symptomatic person with ITP

what if pt is immunosuppresed

A

prednisone, moniter every 4-7 days
don’t give if they have DM
-if immunosuppresed then give IVIG

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13
Q

what does anagrelide do

A

shuts down precursors of platelets

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14
Q

what is acral erythema

A

pts who get erythematous rashes from taking ARA-C on their tips of fingers, toes, penis

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15
Q

what is hand and foot syndrome from taking

A

5-UF

capecitabine

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16
Q

how do you treat erythromelalagia

A

baby aspirin

17
Q

what is the most common of the qualitative platelet disorders

A

bernard soulier syndrome

18
Q

describe bernard soulier syndrome

A

absent aggregation to ristocetin and normal aggregation to everything else
giant platelts

19
Q

desribe glanzmann thrombasthenia

A

normal binding to ristocetin but abnormal to everything else