Pediatric Disease Flashcards
What are the 8 factors of growth failure
- genetically determined short stature
- muscular dystrophy/chromosome disorders
- IUGR - smoking, alcohol, infection, bleeding
- skeletal dysplasia - achondroplasia; supportive care
- constitutional delays in growth and puberty
- malnutrition
- chronic system disorders, eg CHF
- endocrine disorders (hypothyroid)
What is the number one reason for growth failure in the world
Malnutrition
What is the most common endocrine disorder of childhood
Diabetes mellitus
What is the mean age of onset of T1DM and what age are we now seeing it at
Mean age = 12
Now seeing it at 2
What is the presentation of T1DM
- acute onset
- poor appetite and malaise
- hyperglycemia leading to DKA
- emergency
- child is flushed, bright eyed, Kussmaul breathing
What is the most common presentation of T1DM
DKA
Describe the fasting blood glucose in T1DM
Elevated
Treatment for T1DM
Insulin for duration of life
What are some clinical signs of DM
- polyuria, polydyspia
- nocturnal enuresis
- weight loss
- lethargy
- infection
What are the complications of DM in children
- Vascular - artherosclerosis,
- Retinopahty
- Nephropathy
- Neuropathy
- Thyroid
- Celiac disease
Prevalence of retinopathy is most prevalent with a history of
Childhood diabetes
What is a predictor of nephropathy
Microalbuminuria
What are factors leading to nephropathy
HTN
T1DM > 5 years
Poor glycemic control
Lipid abnormalities
Control of _____ alone can slow the progression of nephropathy
BP
_______ control can help with microalbuminuria
Glycemic
What is the best test for evaluation of neuropathy in peds
Motor nerve conduction velocities
What is the most common form of neuropathy
Peripheral sensory neuropathy
Neuropathy can affect which nervous system, leading to impotence, nocturnal diarrhea and postural hypotension
ANS
What is T2DM
Body develops a resistance to insulin and no longer uses insulin properly, As the need for insulin rises, the pancreas gradually loses its ability to produce sufficient amounts of insulin to regulate blood sugar
What is HIV characterized by
T-cel disturbance