Pediatric Cases Flashcards
when does the physiologic nadir for hemoglobin in infants occur?
at approximately 2 months of age
how does anemia effect the homoglobin-oxygen association curve?
the oxygen dissociation curve shifts to the right
how does the rate of onset of anemia affect a patient?
the slower the anemia develops the better the body can compensate. Rapidly developing anemia usually results in more dramatic symptoms
how could you tell if the bone marrow was inadequately responding to a severe anemia?
a low or low-normal reticulocyte count is an inadequate bone marrow response in the face of a significant anemia
what is diamond-blackfan anemia?
congenital pure red blood cell aplasia that almost always presents in infancy
what is occurring in diamond-blackfan anemia?
there is increased apoptosis in erythroid precursors
how does diamond-blackfan anemia look on the peripheral blood smear?
macrocytic with low/inadequate reticulocyte count
what is the most common inherited form of aplastic anemia?
fanconi anemia
when do you get diagnosed with fanconi anemia?
may be up to 10 years old before it presents
how does iron deficiency anemia look on the peripheral smear of a child?
microcytic, hypochromic with increased RDW; target cells on peripheral smears
if a question stems has a pale child and he like to drink a lot of cow’s milk, what should you think?
IDA
how does cyclic neutropenia present?
cyclic fever, oral ulcers, gingivitis, periodontal disease, and recurrent bacterial infections
what is the inheritance pattern for cyclic neutropenia?
autosomal dominant
what are the symptoms associated with Schwachman-Diamond syndrome?
Triad of: neutropenia, exocrine pancreas insufficiency, and skeletal abnormalities
what is the inheritance pattern for Schwachman-Diamond syndrome?
autosomal recessive
