Comprehensive Hematopathology Cases Flashcards
What does it mean when the blasts have granules?
they are trying to become granules–> there are of the myeloid lineage
What stain can you use to identify myeloid blasts?
myeloperoxidase stain
When you diagnose someone with AML, what is the first thing you need to do?
determine if there are any genetic abnormalities associated with it
What makes something a megaloblastic anemia?
when you not only seen macrocytic RBCs but you also see the hyperlobation of the neutrophils
Why are multiple lineages affected by megaloblastic anemia?
DNA synthesis is affected- so both lineage precursors are affects
what are the most common causes of megaloblastic anemia?
inability to properly access B12 and folate
why would someone with a B12 deficiency present with difficulty walking and other CNS symptoms?
the CNS needs B12 for normal myelination of the spinal tract
what is absorption of B12 dependent on?/ what could be a cause of B12 anemia?
intrinsic factor
What could cause loss of intrinsic factor?
gastritis that interferes with the parietal cells that produce intrinsic factor
what is it called when there is a B12 deficiency due to loss of intrinsic factor?
pernicious anemia
how should you treat pernicious anemia?
INJECTABLE B12- not oral because she can’t absorb it
what is the definition of hypersplenism?
splenomegaly + thrombocytopenia (or any other -penia)
what are two examples of when the spleen would destroy platelets?
immune hyperfunction and when platelets have antibodies on them (ITP)
why would the spleen sequester platelets?
congestive splenomegaly can result in excess storage (aka sequestration) of platelets
what could chronic hepatitis B with hepatic cirrhosis lead to?
portal hypertension with congestive splenomegaly
