PEDIATRIC & ADULT HEMATOPOIESIS

Question 1

In newborn: _______ of bone marrow is active

Answer 1

80 – 90%

Question 2

In young adults (age 20): ____ of BM is active (hematopoiesis: proximal ends of large flat bones, pelvis, sternum).

Answer 2

60%

Question 3

In older adults (age 55): ____ bone marrow is active & ____ is fat.

Answer 3

40%, 60%

Question 4

Marrow (red) cells to Fat (yellow) cells ratio

Answer 4

cellularity

Question 5

Marrow has 30-70% hematopoietic cells

Answer 5

Normocellular

Question 6

Marrow has <30% hematopoietic cells

Answer 6

Hypocellular / Hypoplastic

Question 7

Marrow has >70% hematopoietic cells

Answer 7

Hypercellular / Hyperplastic

Question 8

Marrow has <30% hematopoietic cells

Answer 8

Hypocellular / Hypoplastic

Question 9

Marrow has few or no hematopoietic cells

Answer 9

Aplastic

Question 10

myeloid to erythroid ratio (M:E)

Answer 10

Normal is 3:1 or 4:1

Question 11

NOTE

Answer 11

Lymphocytes & monocytes are excluded from M:E ratio

Question 12

Hematopoiesis (+ table)

Answer 12

refer to handout page 1

Question 13

• Total production of RBCs
• Measured thru M:E, fetal urobilinogen, & plasma iron

Answer 13

TOTAL ERYTHROPOIESIS

Question 14

• RBC lifespan was finished. Should reach the peripheral blood to become a normal cell.
• Measured thru RBC turnover utilization of iron
  o Thru retic ct. or iron measurement

Answer 14

EFFECTIVE ERYTHROPOIESIS