ANEMIA DUE TO IMPAIRED RED CELL PRODUCTION Flashcards
1
Q
- Most common form of anemia
- Microcytic/hypochromic anemia
A
IRON DEFICIENCY ANEMIA (IDA)
2
Q
*INCREASED↑:
✓ RDW & TIBC
*DECREASED ↓:
✓ Hgb/Hct
✓ RBC indices
✓ Retic ct.
✓ Serum iron
✓ Ferritin
A
IRON DEFICIENCY ANEMIA (IDA)
3
Q
- Inability to use available normal RBC
- Impaired release of storage iron associated with ↑HEPCIDIN levels
- Normocytic/normochromic anemia, or slightly microcytic/hypochromic anemia
- Associated w/ persistent infections, chronic inflammatory disorders
A
ANEMIA OF CHRONIC DSZ (ACD)
4
Q
*INCREASED↑:
✓ ESR & Ferritin
*DECREASED↓
✓ Serum Iron & TIBC
A
ANEMIA OF CHRONIC DSZ (ACD)
5
Q
- Caused by blocks on the protoporphyrin pathway resulting in defective hgb synthesis & iron overload
- Excess iron accumulates in the mitochondrial region of immature erythrocytes (ringed sideroblasts)
- 2 RBC populations (dimorphic) are seen
- Microcytic/hypochromic anemia
A
SIDEROBLASTIC ANEMIA
6
Q
*INCREASED ↑
✓ Ferritin & serum iron
*DECREASED ↓
✓ TIBC
A
SIDEROBLASTIC ANEMIA
6
Q
Inherited blood disorder that causes body to have less hgb than normal.
A
THALASSEMIA
7
Q
- Multiple blocks in the protoporphyrin pathway
- Normocytic/normochromic anemia w/ characteristic course basophilic stippling
A
LEAD POISONING
8
Q
- Inherited blood disorder characterized by a block in the protoporphyrin pathway
- Heme precursors before the block accumulate in the tissues, & large amounts are excreted in urine/feces
- Photosensitivity, abdominal pain, CNS disorders
- Hematologic findings are insignificant
A
PORPHYRIAS
9
Q
- Defective DNA synthesis causes abnormal nuclear maturation.
- Normal RNA synthesis, cytoplasm isn’t affected.
- Nucleus matures slower than the cytoplasm (asynchronism)
- Caused by either Vit. B12 def of Folic acid def.
- Macrocytic / Normochromic anemia
A
MEGALOBLASTIC ANEMIAS
10
Q
- BM failure
- ↓hgb/hct & retics
- Normocytic/Normochromic anemia
A
APLASTIC ANEMIA
11
Q
- Hypoproliferative anemia caused by replacement of BM hematopoietic cells by malignant cells or fibrotic tissue
- Normocytic/Normochromic anemia
A
MYELOPHTHISIC (BM REPLACEMENT) ANEMIA
