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Repro 6-7 > PED pharm > Flashcards

PED pharm Flashcards

1
Q

what pregnancy category is no risk evident

A

B

-note “A” is just no risk

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2
Q

what pregnancy risk cannot be excluded

A

C

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3
Q

what prego category is warfarin fall under

A

X (contr-indicated)

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4
Q

what does Warfarin block which can cause teratogenic effects, fetal hemorrhage, and fetal death

A

Blood clotting factors (2,7,9,10)

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5
Q

Is postpartum warfarin is useful and safe

A

yes

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6
Q

what drug will you give to HELLP and/or pre-eclampsia bc these things are life threatening

A

corticosteriods

-specifically 9-fluoro-corticosteroids

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7
Q

what is the last organ system to mature sufficiently to support extrauterine life

A

lungs

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8
Q

what is used to treat RDS, neonatal death, and ventricular hemorrhage

A

corticosteroids

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9
Q

When is antenatal corticosteriods indicated when a women as either the following; threatened pre-term labour, antepartum hemorrhage, preterm rupture of membranes, or conditions requiring c-section (pre-eclampsia, HELLP

A

women btw 24 and 34 weeks of gestation

-note his wave suffered from Pre-eclampsia and son needed the roids

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10
Q

what is the drug of choice for fetal lung development

A

two doses of betamethasone 12 mg, i.m. 24 hours apart

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11
Q

what is the path of corticosteroid mechanism of action

A

1) GCR binding 2) dissociation 3) dimerization 4) translocation

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12
Q

Single course of this medication has no significant maternal or fetal adverse effects. But multiple courses for (~7 days) risk side effects

A

betamethasone or dexamethasone

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13
Q

what are some contraindications for antenatal corticosteriods

A

mother w/ systemic infection, TB

-bc immunosuppression

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14
Q

why dont we just give cortisol to the fetus

A

placenta metabolizes (inactivates) cortisol

  • pacenta is rich in 11beta-hydroxy steroid dehydrogenase-2 (11B-HSD-2)
  • fetus will be exposed to cortisone
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15
Q

what drug class is used in pre-term delivery

A

Tocolytic agents

-relax uterine smooth muschle

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16
Q

which tocolytic is a B-2 adrenergic receptor relaxes uterine smooth muscle

A

Terbutaline and Ritodrine

17
Q

Very useful to delay delivery for 24-48 hours, which allows time for a concurrent course of corticosteriods to act in a pre-term birth (24-32 weeks)

A

MgSO4

18
Q

what tocolytic drug is a COX inhibitor which blocks uterine PGF2alpha formation

A

Indomethacin

19
Q

what tocolytic drug is a Ca channel which relaxes uterine smooth muscle

A

Nifedipine

20
Q

which tocolytic drug has an adverse effect of acute onset pulmonary edema

A

Terbutaline and Ritodrine

21
Q

which tocolytic drug is contraindicated in maternal platelet dysfunction or bleeding disorder, hepatic dys, GI ulcers, renal dys, or asthma

A

Indomethacin

22
Q

Tocolytic drug who has an adverse effect of hypotension, reflex tachycardia

A

Nifedipine

23
Q

which drug is contraindicated in myasthenia gravis

A

MgSO4

24
Q

what drug used in the third trimester can cause maternal complications include prolongation of labor, postpartum hemorrhage, and gastric irritation

A

NSAID

25
Q

what drug used in third trimester has fetal adverse effects ranging from oligohydramnios and intrauterine closure of the ductus arteriosus to persistent pulmonary hypertension and fetal death

A

NSAID

26
Q

Drug that maintains a PDA

A

PGE1 (alprostadil)

-note to close PDA use indomethacin which inhbits PGE2

27
Q

what is indomethacin not effective in closing PDA

A

PDA in a full term baby

-used in premature infants

28
Q

what are some complications seen in PGE1 (alprostadil)

A

hypotension, tachycardia, apnea

29
Q

what is a good proxy of GFR

A

urine output

30
Q

what drug can cause neonatal encephalopathy due to bilirubin displacement and poor bilirubin clearance

A

Sulfonamides cause kernicterus

31
Q

what phase II enzyme which is responsible for hepatic ontongeny can cause gray baby syndrome

A

impaired glucuronidation in neonates

-the drug used is chloramphenicol

32
Q

what displaces bilirubin from albumin

A

SMX

33
Q

what pregnancy category are fluoroquinolones and trimethoprim

A

Pregnancy C

-birth defect risk

34
Q

what prego category do we see tetracyclines

A

Prego D

-see fatty liver, hepatotoxicity, stains teeth

35
Q

Do not admister age <18. Bc they cause cartilage erosion

A

Fluroquinolones

36
Q

Do not administer age < 8. Bc see bone, and teeth deposits

A

Tetracyclines

37
Q

what should we avoid to treat a fever & pain associated w/ viral illnesses. peak provalence is ~6 yrs of age

A

avoid aspirin. give acteminophen instead

Repro 6-7 (6 decks)

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