Pearls from AAMC/ Khan Academy

Question 1

Since enantiomers have different orientations, they would likely not react similarly with another chiral reagent.
Therefore, the following properties would be expected to be identical between (R)-citalopram and (S)-citalopram: ______ _____, IR spectrum, and rate of reaction with the same achiral reagent.

Answer 1

boiling point

Question 2

It is acceptable to assume that ___________ drugs generally have a higher volume of distribution in the body due to the volume of fatty tissue present.

Answer 2

lipophilic

Question 3

Uncompetitive inhibition takes places upon the binding of an inhibitor to an _____-_____ _____.

Noncompetitive antagonism is either due to allosteric binding (binding to a site other than the active site) of an inhibitor to an enzyme, or permanent active site binding.

Answer 3

enzyme-substrate complex

Question 4

SN2 reactions proceed best with ______ substrates are a _-step reaction

Answer 4

primary
1-step

(Princeton Review, Practice Exam 1)

Question 5

Lyases are enzymes that cleave bonds without the addition of _____.

Answer 5

water

(Princeton Review, Practice Exam 1)

Question 6

Competitive inhibitors increase the apparent __ of inhibited enzyme for substrate by competing with substrate for access to the enzyme active site.

Answer 6

K_m

(Princeton Review, Practice Exam 1)

Question 7

Competitive inhibitors do not affect the catalytic __________, and thus do not affect the k_cat, for the inhibited enzyme.

Answer 7

efficiency

(Princeton Review, Practice Exam 1)