Pearls extra

Question 1

Dosing dabig

Answer 1

BD
also apix

rivarox just daily

Question 2

What new agent reverses dabig bleeding in minutes

Answer 2

Idracizumab

Question 3

Unprovoked DVT what proportion cancer?

Answer 3

10%

Question 4

Males or females higher recurrent DVT

Answer 4

males

Question 5

types VWD

Answer 5

1- low level
2-qualitative abnormality
3- severe deficiency that presents like haemophilia

Question 6

indications for treatment in CLL

Answer 6

plt under 100
hb under 110

or

disabling B symptoms
massive hepatospleg or LN
cytopaenias from BM failure
lymph doubling under 3 months

Question 7

pregnancy and clotting factors

Answer 7

increase V and VII

low C and S

Question 8

IGF is made by what in response to what

Answer 8

liver in response to GH excess

Question 9

Iron absorbed in the
folate absorbed in the
B12 absorbed in the

Answer 9

iron - duodenum
folate- jej
B12- ileum

Question 10

ITP… TPO levels low or high

Answer 10

inappropriately low!

Question 11

What activates factor C

Answer 11

thrombin-thrombomodulin complex

then in conjunction with cofactor protein S–>inactivation of factors V and VIII

Question 12

Prostacyclin action

Answer 12

1. mostly inhibits plt plug formation

2. vasodilator

Question 13

Long APTT
then on mixing sort of normalises
but leave for a few hours and long again

Answer 13

weak inhibitor

Question 14

Best way to tell Aplastic anaemia from MDS

Answer 14

small, aberrent mega K in MDS

no Mega K in AA

Question 15

what is matched in bone marrow HLA

Answer 15

A
B
C
DRB1

Question 16

Rituximab induced lymphopaenia- how long to recover after stopping

Answer 16

6-9 months

Question 17

necrosis on warfarin of skin, think…

Answer 17

protein C deficiency!