MDS Flashcards
1
Q
Smear
A
Ringed sideroblats Mild macrocytosis Hypo segmented neuts - pseudo pelger huet cells Punctate basophilia in red cells Oval macrocytosis Dimorphism red cells
2
Q
Marrow
A
Hyper cellular
Displastic changes one or more
Increase myeloblasts and mid stage bulge unlike acute leukaemia
3
Q
Negative prognostic markers
A
P53 FLT3 Beta 2 micro Cd34 positive nucleated BM cells Therapy related Increase willis tumour gene 1 wtg1 Complex karyOTYPE
4
Q
Mds treat
A
Allo only curative but high risk and rarely done as old,g
AZACITADINE demethylator superior remission
Lenalidomide 50 percent remission in del 5q
Transfusion minimise
Erythropoetin and gcsf
5
Q
Diagnosis
A
Home marrow dysphasia with more than 10 percent of the cells with a specific myeloid lineage
If over 20 then aml
