last lot

Question 1

cytogenetic change in most follicular lymphomas

Answer 1

bcl-2 oncogenet

t(14;18)

Question 2

CLL- what kind of cell?

Answer 2

asians- T cell

westerns- B cell

Question 3

CLL bad

Answer 3

Zap 70
del 17q13
p53

Question 4

Hodgkins- lymphocyte deplete or predominant best prog?

Answer 4

lymphocyte deplete worse prognosis

Question 5

NK flow cytom

Answer 5

16, 56, 57

Question 6

B cell flow

Answer 6

19,20,22

also follicular often CD10- immature B cells

some indolent lymphomas often pinch some T cell markers to confuse you - CD5, CD43

Question 7

T cell flow

Answer 7

CD 2,3,5,7

and 4 and 8

Question 8

Mantle flow

Answer 8

CD 5 pos

CD 23 neg

Question 9

CLL flow

Answer 9

CD 23

CD5

Question 10

myeloid flow

Answer 10

CD 13

CD33

Question 11

MDS presentation

Answer 11

rarely present with opportunistic infection as B and T cells work fine

Question 12

improve survival in MDS

Answer 12

azacitadine

Question 13

how does deferasirox work?

Answer 13

oral, binds Fe3+

Question 14

acquired vs inherited factor VIII def

Answer 14

in inhibitor acquired will not correct study

in congen haemophilia will correct

Question 15

VWD usual inheritance

Answer 15

AD

Question 16

VW factor in haemophilia

factor 8 in VWD

Answer 16

in VWD factor 8 is low

in haemophilia, VWfactor is normal

Question 17

How do you bypass a factor 8 inhibitor

Answer 17

give factor VIIa

can also try immune tolerance induction/desensitisation

Question 18

desmopressin which haemophilia

Answer 18

A only

not b

Question 19

What is peak HIT onset?

Answer 19

5-10 days or one day if previous exposure in last 30 days

drop over 50 percent from highest reading post starting hep, still over 20 count

no other reason

new thrombosis

Question 20

Why no warfarin in acute HIT

Answer 20

risk skin necrosis and venous gangrene during initiation
wait until plt over 150 , and overlap for 5 days

if with thrombosis- 3 months
if wihtout thrombosis - 1 month

if down track need PCI- use bivalirudin or argatroban
if down track totally recovered and immuno assay neg- can use UFH intra op for cardiac and valve surgery. If assay positive, use bivalirudin

Question 21

DIC chronic vs acute

Answer 21

both have high fibrin deg products and d dimer up
THROMBIN TIME normal to slight increase in chronic- up in acute
factor levels and PT and APTT normal in chronic