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BIOC 221 - Metabolism > PDH and CAC > Flashcards

PDH and CAC Flashcards

1
Q

Where does the CAC occur?

A

In the mitochondria

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2
Q

In order for the PDH complex to run, what 2 crucial molecules are required?

A

Pyruvate and oxygen

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3
Q

What vitamin does TPP come from?

A

B1

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4
Q

What vitamin does CoA-SH come from?

A

B5

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5
Q

What vitamins does FAD come from?

A

B2

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6
Q

What vitamin does NAD+ come from?

A

B3

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7
Q

If you are B1 (Thiamine) deficient, what disease could you get?

A

Beriberi

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8
Q

How much energy is produced from the PDH complex?

A

1 NADH per pyruvate = 2.5 ATP

2 per glucose = 5 ATP

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9
Q

How much energy is produced from CAC?

A

10 ATP per acetyl coA (20 per glucose)

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10
Q

How much energy is produced from both PDH and CAC?

A

12.5 ATP per pyruvate (or 25 ATP per Glucose)

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11
Q

How much energy is produced from glycolysis?

A

7 ATP per glucose (2 NADH and 4 - 2 ATP)

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12
Q

How much energy is produced from glycolysis + PDH + CAC

A

30 - 32 ATP

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13
Q

How much ATP does glycolysis use?

A

2 ATP

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14
Q

ATP can be regenerated from ADP by any nucleoside triphosphate with no net energy expenditure? (T/F)

A

True, (NTP + ADP ATP + NDP; deltaG’= 0)

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15
Q

Consider a favourable reduction-oxidation (redox) reaction: the reactant that is reduced will have a less positive reduction potential. (T/F)

A

False, when a molecule gains e- it is gaining volts (VE) and it becomes more positive

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16
Q

Enzyme coupling increases the reaction rate by:

A

eliminating product/substrate diffusion

17
Q

Phosphocreatine is an energy storage molecule that can be used to regenerate NAD+ for muscle contraction. (T/F)

A

False, phosphocreatine is used in muscle tissue to replenish ATP after contraction.
Phosphocreatine + ADP Creatine + ATP

18
Q

Biological systems often transfer reducing equivalents to the electron transport chain in the form of hydrogen or hydride atoms that are part of electron carriers to prevent what?

A

Damage to the cell

19
Q

The glycolytic reactions that are good candidates for regulation are those that catalyze reactions that are:

A

Very favorable

20
Q

ATP is generally involved in reactions that transfer a phosphate group. (T/F)

A

False, ATP is involved with the transfer of a phosphoryl group, not phosphate.

21
Q

A reaction is at equilibrium if it has a Keq value of one. (T/F)

A

True

22
Q

Pyruvate dehydrogenase converts pyruvate to acetyl-CoA and CO2. (T/F)

A

True, see PDH

23
Q

Where does the PDH complex reside?

A

mitochondria

BIOC 221 - Metabolism (6 decks)

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