Pcyh Flashcards
Not considered first-line drugs in the tx of depression bc of their adverse effect profile, which includes the risk of hypertensive crises from consumption of tyramine-containing foods and the serotonin syndrome if they are used concomitantly with SSRIs
MAOIs
Serotonin-specific reuptake inhibitors inhibit reuptake of serotonin from the neuronal synapse without having significant effects on what?
Reuptake of NorEpi and/or dopamine
The most widely prescribed class of antidepressants and are the drug of choice to treat mild to moderate depression
SSRIs
A potentially life-threatening adverse drug reaction that may occur with therapeutic drug use, overdose, or interactions b/w serotoninergic drugs
Serotonin syndrome
Symptoms of serotonin syndrome
Agitation, delirium, autonomic hyperactivity, hyperreflexia, clonus and hyperthermia
Inhibit norepinephrine and serotonin and tyramine breakdown, so there is more norepinephrine and serotonin available for release
MAOIs
The most dreaded occurrence of side effects with MAOIs is very significant hypertension if pts ingest what or receive what?
Foods containing tyramine (cheese, wines);
Receive sympathomimetic drugs
Which anesthetic should be avoided with MAOIs
Ketamine
______ is the mainstay treatment of Bipolar disorder, but antiemetic drugs such as carbamazepine and valproate are often used
Lithium
What is the dopamine hypothesis concerning the etiology of schizophrenia?
Suggests the disorder is a result of a neurotransmitter (dopamine) dysfunction
What is the first step in treating someone with drug overdose?
Secure the airway and support ventilation and circulation
A shared site of action for ___, ___, & ___ is consistent with the ability of these different classes of drugs to produce cross-tolerance and cross-dependence
Alcohol, benzos, & barbiturates
What drug can be given to treat alcoholism?
Disulfiram
_______ produces sympathetic stimulation by blocking presynaptic uptake of NorEpi and dopamine and thereby increases postsynaptic concentrations of these neurotransmitters
Cocaine
____ & ____ sleep times are prolonged in THC-treated animals, and opioid-induced respiratory depression may be potentiated
Barbiturate & ketamine
