PCOS Flashcards

1
Q

What is PCOS

A

Anovulation disorder that results in Hirsutism, infertility and AUB
Common presents in young

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2
Q

Symptoms and signs

A
HAIR- AN
Hirsutism
Hyperandrogenism
Infertility
Insulin Resistance
Acanthuses Nigricans
Other 
teens to young adults
Oligomenorrhea
acne
hirsutism
Abnormal/irregular uterine bleeding, 
obesity
virilization
FmHx of DM
Associated with
Syndrome X - refer to notes
obesity
infertility
HTN
Insulin resistance that can develop into T2D
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3
Q

Diagnosis of PCOS

A

Diagnosis based on 2 of any of the following 3 and and exclusion of other aetiologies such as hyperthyroidism, hyperprolactinaemia, congenital adrenal hyperplasia, androgen-secreting tumours and Cushing’s syndrome.
oligomenorrhea/irregular menses for 6 mo
clinical or lab evidence of hyperandrogenism
polycystic ovaries on U/S

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4
Q

Cx of PCOS

A
Risk of endometrial hyperplasia and cancer
Long term health consequences
Hyperlipidemia
Adult onset DM
endometrial hyperplasia
Infertility
Obesity
Sleep apnea
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5
Q

Ix

A
17 hydroxyprogesterone level should be normal
Prolactin, free testosterone, DHEA
TFT
LH:FSH = 2:1
USS: TA, TV
OGTT
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6
Q

Mx

A
6 steps
1. Wt loss, Laser hair removal, lifestyle changes
2. COCP
3. anti androgens - Spirolactone.
4. Clomiphine - if you want to have babies - Infertility
5. metformin.
6. Manage CVS risk factor
7 . Pys support
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