PCOS

Question 1

What is the presentation for a pt with PCOS?

Answer 1

Irregular menses, infertility, hirsutism

Question 2

What are the three criteria for dx PCOS and how many do you need to be diagnosed?

Answer 2

oligo/anovulation, polycystic ovaries on US, and clinical or biochemical signs of hyperandrogenism
You need 2/3 to give the dx.

Question 3

What endocrine changes do you expect to see in PCOS?

Answer 3

increased LH compared to FSH
Increased androgen production from theca lutein cells which leads to an increasein testosterone

note that FSH tends to be normal in PCOS

Question 4

Longstanding PCOS increases a pt’s risk for _____________________ due to the chronic anovulation resulting in prolonged exposure of the endometrium to unopposed estrogen

Answer 4

Endometrial cancer