PCAL Flashcards
DIMENSIONAL ANALYSIS is aka
Factor analysis, factor-label method or unit factor method
Involves the logical sequencing and placement of a series of ratios (factors) into an
equation
DIMENSIONAL ANALYSIS
FUNDAMENTALS OF PHARMACEUTICAL CALCULATIONS
Roman Numerals
¡ Fractions
¡ Ratio and Proportion
¡ Dimensional Analysis
METRIC SYSTEM is aka
SI units
International system of unit
Internationally recognized decimal system of weights and measures
METRIC SYSTEM
Developed in the late 1700s in order to replace a system with a rational system that
is based on multiples of 10
METRIC SYSTEM
Metric system is Developed in the late 1700s in order to replace a system with a rational system that
is based on multiples of ______
10
Metric system is Developed in the late __ in order to replace a system with a rational system that
is based on multiples of ______
1700s
Metric system of mass
Kg
Metric system of volume
Cubic meter or m3
Metric system of length
Meter
Metric system of time
Seconds
Metric system of electric current
Ampere
Metric system of amount if substance
Moles
Metric system of temperature
Kelvin
Metric system of luminous intensity
Candela
Traditional system of pharmacy
Avoirdupois
Used by wholesalers and
manufacturers in providing
pharmacist powdered drugs or
chemicals in bulk or stock packages
Avoirdupois
Common system of commerce
Apothecary
Used by pharmacist in weighing
ingredients for compounding
prescriptions
Apothecary
Apothecary mostly used measurements. What is the conversion for fluid
Gallon
Quarts
Pints
Fluid ounce
Fluid drams
Minimns
4 2 16 8 60
Apothecary mostly used measurements. What is the conversion for weights
Pounds
Ounce
Drams
Scr
Grains
12 8 3 20
Avoirdupois system conversion
1 pound = 16 oz = 7,000 grains
Least accurate, but easily understood by patients
Household system
Household System
20 drops
1 tsp
1 dessert spoon
1 tbsp
1 oz
1 wine glass
1 teacup
1 glass
20 drops- 1 mL
1 tsp- 5 mL
1 dessert spoon- 8 mL
1 tbsp- 15 mL
1 oz- 30 mL
1 wine glass- 60 mL
1 teacup- 180 mL
1 glass- 240 mL
Nancy lost 5 Fingers and 160 pesos
SI
conversion of Temperature
9C = 5 F -160
Intersystem Conversion
inch → cm
2.54 cm
mL → min
16.23 min
fl oz → mL
29.57 mL
fl dr → mL
3.69 mL
pt → mL
473 mL
gal → L
3.785 L
gr → mg
65 mg
kg → lbs
2.2 lbs
lb → g
454 g
Degree of compactness
Density
Mass per unit volume of a substance
Density
Ratio of the weight of the substance
to the weight of an equal volume of a
substance chosen as a standard
Specific gravity
Standard for solid and liquid: water
Specific gravity
Standard for gas: hydrogen
Specific gravity
Specific gravity: Standard for solid and liquid: _______
Water
Specific gravity: Standard for gas: _______
Hydrogen
Volume per unit mass of a substance
Specific volume
Reciprocal of density
Specific volume
Formula for density
d= g/ mL
Formula for sg
Sg= density of substance/ density of standard
Formula for specific volume
mL / g
Calculation of specific gravity
Archimedes Principle /
Displacement Method
Pycnometer Method
Formula for Pycnometer Method
Wt with substance - weight of empty/ wt with the standard - wt of empty
Archimedes Principle /
Displacement Method formula
Wt in air- wt in substance/ wt in air - wt in standard
Number of parts in a hundred
PERCENTAGE STRENGTH
Define the concentration or strength of a pharmaceutical preparation as well to determine the
quantity of the component
PERCENTAGE STRENGTH
Quantify a parameter in a clinical study
PERCENTAGE STRENGTH
Describe the accuracy of a method or procedure
PERCENTAGE STRENGTH
Quantify a parameter in a clinical study
Percentage strength
What are the example of percentage strength for weights per volume
Suspension diluted acid and usp
What are the example of percentage strength for volume per volume
Emotion and hydrocelenoic acid
What are the example of percentage strength for weights per weight
Semisolids and solid
What are the example of percentage strength for mg per 100 mL
Biological concentration which are very potent
One part of solute to the nth part of the solution
RATIO STRENGTH
Used to express concentrations of very weak pharmaceutical preparations
RATIO STRENGTH
Express strengths of very dilute solution
PPM / PPB
Quantify the presence of trace amounts of contaminants in water and food
PPM / PPB
Defined as an aqueous solution containing 50% v/v of
alcohol
Proof spirit
In India: mixture of absolute alcohol and water, which is
57.1 % v/v or 48.24% w/w (100 proof)
Proof spirit
Overproof:
> 57.1% v/v
Underproof:
< 57.1% v/v
Taxable unit of alcohols and alcoholic beverages
Proof gallons
Formula for proof strength
2 multiply by percentage volume per volume
Formula for proof gallon
Wine gallon x 90/ 50
Or
Wine gallon x proof / 100
Molecular weight of a substance in
grams
Mole (mol)
Molecular weight of a substance in
milligrams
Millimole (mmol)
Molecular weight of a substance in
microgram
Micromole (mcmol)
Formula for mole
G/ Molecular weight
Formula for millimole
mg/ MW
Or mole x 1,000
Formula for micromole
mcg/ MW
Or mole x 1,000,000
It is used to measure osmetic concentration
Milliosmol
number of moles of solute per L of
solution
Molarity
number of moles of solute per kg of
solution
Molality
gram-equivalent weight of solute per
L of solution
Normality
Formula of Molarity =
number of moles (mol)/
L solution
Formula of molality
Molality =
number of moles (mol)/
kg solution
Formula of normality
Normality (N) - gram-equivalent weight of solute per
L of solution
Symbol of molality, molarity and normality
molality m
molarity M
and normality N
Used to express the concentration of electrolytes in a solution
EQUIVALENT AND MILLIEQUIVALEN
Unit used to measure the chemical activity of an electrolyte in a solution
EQUIVALENT AND MILLIEQUIVALEN
Milligrams of solute equal to 1/1000 of its gram equivalent weight (GEW), taking into
account the valence of the ions
EQUIVALENT AND MILLIEQUIVALEN
No dissociation
Non-electrolytes
i- factor of non electrolytes
1
Example of non electrolytes
Organic compounds
80% dissociation
Weak electrolytes
Example of weak electrolytes
Weak acids weak ways and salts at high concentration
Example of strong electrolytes
Strong acids and strong bases and the salts at low concentration
100% dissociation
Strong electrolytes
Arithmetical method of solving problems that involves the mixing of solutions or
mixtures of solids possessing different percentage strength
Alligation
The weighed average of a mixture of
two or more substances of known
quantity and concentration may be
calculated
Alligation medial
Used to calculate the number of
parts of two or more components of
a given strength when they are to be
mixed to prepare a mixture of
desired strength
Alligation alternate
Differentiate allogation medial amd alligation alternate
Alligation medial
-Volume and concentration
- Final product
Alligation alternate
- proportion
- ingridients
Two types of alligation
Alligation medial and alligation alternate
Quantitative amount that is administered or taken by a patient for the
intended medicinal effect
Dose
Amount of drug taken at one time
Single dose
Total amount of drug taken during the dose of therapy
Total dose
Dose that is subdivided (2 times, 3 times)
Divided dose
Schedule of dosing
Dosage regimen
Amount that ordinarily produces the medicinal effect intended in the adult
patient
Usual adult dose
Amount that ordinarily produces the medicinal effect intended in the
infant/child patient
Usual pediatric dose
Quantitative range or amounts of the drug that may be prescribed within
the guidelines of usual medicine practices
Usual dosage range
< 18.5
Underweight
18.5 to 24.9
Normal
25 to 29.9
Overweight
30 to 39.9
Obese
> 40
Extremely obese
Defined as weight for height at the lowest risk of mortality