PBL2 2 Flashcards
define firboscan
this si a speiclaised ultrasound machine for you liver, it measures the fibrosis and steatosis change in the liver
ilteric
presence of jaundice seen in the slcera of the eye
AST/ALT ratio
ratio between asparate transaminase and alanine transaminsase, this is used to differenaited between various causes of liver disease
gamma GT
transferase enzyme that catlayses the transfer of gamma-glutamyl functional groups from molecules such as glutathione to an acceptor that may be an amino acid, peptide or water
diagnostic tap for ascites
needle or caterh placed into the periotoneal cavity to obtain ascitic fluid for diagnostic purposes
Terlipressin
it is a vasopressin and is sued as a vasoactive drug in the manegemtn of low blood pressure
encephalopathy
disease in which the functioning of the brain is affected by some agent or condition
oral lactulose
sugar derived medication used to treat hepatic encephalopathy
empirical antibiotics
broad-specturm , given use regular given for many thigns
what is the causes of cirrhosis
- Alcohol
- Fat/metabolic syndrome
- HBV/HCV
- Billary disease – PBC/PSC
- Autoimmune
- HC/wilsons/amyloid
what re the signs and symptoms of cirrhosis
Symptoms - Not any specific - Weight loss and tiredness - Cholestatic – pruritis, pale stools/dark urine due to bilirubin increased production Signs - Clubbing - Glynasematic – failure ot breakdown oestrogen - Leuchonychia – pale nails - Palmar erythema - Spider naevi - Hair loss - Proximal wasting - Scratch marks - Xanthelasma
How do you diagnose cirrhosis
liver biopsy
child-turrocte-pugh score
fibroscan
blood tests
describe how to do a liver biopsy
– stain for scar tissue and shows how much scarring they have GOLD STANDARD
describe a child turoccote-pugh score
- bilirubin - as the amount of bilirubin increases the score increases
- albumin - as the amount of albumin increases the score increases
- prothrombin score as the prothrombin time increases the score increases
- hepatic encephopahty symptom grade - as this gets more controlled the points increase
- asicites - as this gets worse the points increase
- each of the 5 points can be given a mark of 1 to 3 depending on severity
- the lowest score you can get is 5
- 5-6 is class A where your. liver is compensated and works normally
- 7-9 class B and 10-15 class C this is when the liver is decompensated and does not work properly
describe a fibroscan
- Electrography – ultrasound like techniqieu
- Stiffness of the liver is translated in terms of kilopascal
- Non invasive, painless alternative to the liver bispy
describe blood tests done
- Bilirubin
- AST/ALT
- Alkaline phosphate
- Gamma GT
- Platelt count – this is important in checking liver disease progression, as liver disease progressive the platelet count decreases
- • Bilirubin
- – Unconjugated vs conjugated
- • Aspartate aminotransferase (AST) – hepatocyte release
- – Mitochondrial enzyme
- – Heart/muscle/kidney
- – hepatitis
- • Alanine aminotransferae (ALT) – hepatocyte release – involved in moving amino groups to make new amino acids from keotacids
- – Liver specific
- • Alkaline phosphatase
- – Bile cannalicular + sinusoidal membranes
- – Bone/placenta it is also present in here, can be high in pregnancy
- – Cholestasis – intra/extrahepatic
- • Gamma glutamyl transpeptidase (GGT)
- – Hepatocellular
- – Cholestasis
- – Alcohol often associated
- – Made in liver and biliary cells
- If AST>ALT – alcohol
- If ALT>AST – viruses or non alacolic fatty liver disease
what is compensated liver disease
- This is a pathological diagnosis made from anatomical or histological study
- Asymptomatic
- Liver can still function
- Circles of fibrous seen in the liver
what is decompensated liver disease
liver failing to work