PBL 4- Depression Flashcards
1
Q
Depression is higher in
A
Women
2
Q
Bipolar depression: (2)
A
Oscillates between depression and mania (excessive exuberance, confidence and enthusiasm)
Inherited
3
Q
Monoamine theory of depression:
A
Decrease noradrenaline and serotonin transmission
4
Q
Relapse rate of depression =
A
50-60%
5
Q
Tri-cyclic antidepressants (TCAs)
- Examples (2)
- How they work (1)
- Side effects (2)
A
- Imipramine, amitriptyline
- TCAs work by preventing this reabsorption of noradrenaline and serotonin back into the nerve cells
- Postural hypotension, muscarinic effects (constipation, dry mouth)
6
Q
Monoamine oxidase inhibitors (MAOIs)
- Examples (3)
- How they work
- Side effects (1)
- Effective in ..% of patients
A
- Phenelzine, tranylcryptomine, moclobemide
- Inhibit irreversible Monoamine oxidases
- CHEESE EFECT - severe headaches, hypertensive crisis, - due to protection of tyramine present in food as MAO inhibited
- 70%
7
Q
Selective Serotonin reputable inhibitors
- Example (1)
- Why their favourable
- Increase the risk of …
A
- Fluoxetine
- Less side effects e.g. Headache, GI upset
- Suicide
8
Q
Serotonin/noradrenaline reuptake inhibitor
- Example (1)
A
- Venlafaxine
9
Q
Noradrenaline reuptake inhibitors:
- Example (1)
A
Reboxetine
10
Q
Atypical antidepressant drugs
- Example (1)
A
Nefazodone
11
Q
Reduced compliance as …
A
Negative side effects appear before benefits
12
Q
Suicide risk in depressed patients =
A
15%
13
Q
Unipolar depression: (2)
A
Develops later in life
Due to adverse life experiences
